caa a22 4500 463185323 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-005-0279-5 doi (NATIONALLICENCE)springer-10.1007/s00726-005-0279-5 Adrenomedullin: molecular mechanisms and its role in cardiac disease [Elektronische Daten] [B. Yanagawa, N. Nagaya] Summary.: Adrenomedullin (AM) is a potent, long-lasting vasoactive peptide originally isolated from human pheochromocytoma. Since its discovery, serum and tissue AM expression have been shown to be increased in experimental models and in patients with cardiac hypertrophy, myocardial infarction and end-stage heart failure with several beneficial effects. Considerable evidence exists for a wide range of autocrine, paracrine and endocrine mechanisms for AM which include vasodilatory, anti-apoptotic, angiogenic, anti-fibrotic, natriuretic, diuretic and positive inotropic. Thus, through regulation of body fluid or direct cardiac mechanisms, AM has additive and beneficial effects in the context of heart disease. Notable molecular mechanisms of AM include cyclic adenosine monophosphate, guanosine-3′,5′-monophosphate, PI3K/Akt and MAPK-ERK-mediated cascades. Given the endogenous and multifunctional nature of AM, we consider this molecule to have great potential in the treatment of cardiovascular diseases. In agreement, early experimental and preliminary clinical studies suggest that AM is a new and promising therapy for cardiovascular diseases. Springer-Verlag, 2006 Keywords: Adrenomedullin - Heart disease - Signaling nationallicence Yanagawa B. Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan aut Nagaya N. Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan aut Amino Acids Springer-Verlag 32/1(2007-01-01), 157-164 0939-4451 32:1<157 2007 32 726 https://doi.org/10.1007/s00726-005-0279-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-005-0279-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yanagawa B. Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan aut NATIONALLICENCE 700 1- Nagaya N. Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka, Japan aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 157-164 0939-4451 32:1<157 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer