caa a22 4500 46318534X CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-005-0282-x doi (NATIONALLICENCE)springer-10.1007/s00726-005-0282-x Decreases in taurine levels induced by β-alanine treatment did not affect the susceptibility of tissues to lipid peroxidation [Elektronische Daten] [H. Parıldar-Karpuzoğlu, S. Doğru-Abbasoğlu, J. Balkan, G. Aykaç-Toker, M. Uysal] Summary.: We aimed to investigate the effect of decreased taurine levels on endogenous and induced lipid peroxide levels in liver, brain, heart and erythrocytes as well as prooxidant and antioxidant balance in the liver of rats administered β-alanine (3%, w/v) in drinking water for 1 month to decrease taurine levels of tissues. This treatment caused significant decreases in taurine levels of liver (86%), brain (36%) and heart (15%). We found that endogenous and ascorbic acid-, NADPH- and cumene hydroperoxide-induced malondialdehyde (MDA) levels did not change in the liver, brain and heart homogenates following β-alanine treatment. Also, H2O2-induced MDA levels remained unchanged in erythrocytes. In addition, we did not observe any changes in levels of MDA, diene conjugates, glutathione, α-tocopherol, ascorbic acid and the activities of superoxide dismutase, glutathione peroxidase and glutathione transferase in the liver. According to this, buffering or sequestering capacity of tissues to exogenous stimuli was not influenced by reduced taurine levels in tissues of rats. Springer-Verlag, 2006 Keywords: Taurine - β-Alanine - Lipid peroxidation - Antioxidants - Rats nationallicence Parıldar-Karpuzoğlu H. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut Doğru-Abbasoğlu S. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut Balkan J. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut Aykaç-Toker G. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut Uysal M. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut Amino Acids Springer-Verlag 32/1(2007-01-01), 115-119 0939-4451 32:1<115 2007 32 726 https://doi.org/10.1007/s00726-005-0282-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-005-0282-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parıldar-Karpuzoğlu H. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut NATIONALLICENCE 700 1- Doğru-Abbasoğlu S. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut NATIONALLICENCE 700 1- Balkan J. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut NATIONALLICENCE 700 1- Aykaç-Toker G. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut NATIONALLICENCE 700 1- Uysal M. Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, Çapa, Istanbul, Turkey aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 115-119 0939-4451 32:1<115 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer