caa a22 4500 463185374 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-005-0357-8 doi (NATIONALLICENCE)springer-10.1007/s00726-005-0357-8 Alterations in D -amino acid levels in the brains of mice and rats after the administration of D -amino acids [Elektronische Daten] [A. Morikawa, K. Hamase, T. Inoue, R. Konno, K. Zaitsu] Summary.: To mutant ddY/DAO− mice lacking D-amino-acid oxidase activity and normal ddY/DAO+ mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pineal glands in both strains. In the ddY/DAO+ mice, the levels of the other D-amino acids did not significantly change in most of the brain regions. While in the ddY/DAO− mice the levels of D-Ser significantly increased in most of the brain regions except for the cerebrum and hippocampus. The levels of D-Ala and D-Leu increased in all regions but the levels of D-Pro did not significantly change. The same five D-amino acids were intravenously injected into Wistar rats and the D-amino acid levels in their brains were examined for 60 min after the administration. The levels of D-Asp markedly increased in the pineal gland 3 min after the administration, while the levels of D-Ser, D-Ala, and D-Pro increased both in the pineal and pituitary glands, the levels of D-Leu increased in all brain regions. These results are useful for the elucidation of the origins and regulation of D-amino acids in the mammalian body. Springer-Verlag, 2006 Keywords: D -Amino acid - Brain distribution - D -Amino-acid oxidase - HPLC nationallicence Morikawa A. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut Hamase K. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut Inoue T. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut Konno R. Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan aut Zaitsu K. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut Amino Acids Springer-Verlag 32/1(2007-01-01), 13-20 0939-4451 32:1<13 2007 32 726 https://doi.org/10.1007/s00726-005-0357-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-005-0357-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morikawa A. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Hamase K. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Inoue T. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Konno R. Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan aut NATIONALLICENCE 700 1- Zaitsu K. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 13-20 0939-4451 32:1<13 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer