caa a22 4500 463185420 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-006-0353-7 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0353-7 Is there a correlation between age and D -aspartic acid in human knee cartilage? [Elektronische Daten] [G. Fisher, S. Lopez, K. Peterson, T. Goff, I. Philip, R. Gaviria, N. Lorenzo, M. Tsesarskaia] Summary.: L-Aspartic acid (L-Asp) is one of the fastest racemizing amino acids such that the abnormal D-form (D-Asp) has been found in stable biological human tissues such as dentin in teeth, eye lens and brain. Earlier reports showed that there was a linear correlation between age and D-Asp in teeth. We have previously reported that significant levels of D-Asp were found in normal and osteoarthritic knee cartilage. Since cartilage is a slow regenerating tissue, we hypothesized that D-Asp should accumulate in knee cartilage and that there might be a correlation between the age of the person and the amount of D-Asp found in cartilage. Our analysis of approximately 100 samples of normal knee cartilage showed that there are detectable amounts of D-Asp (2-4% of total Asp) in knee cartilage. However, there was only a slight correlation (r = 0.35) between the age of the person and the amount of D-Asp (nmoles/g). Surprisingly, there was a better correlation between age and the amount of D-Asp in the male subjects (r = 0.57) than in the female subjects (r = 0.21). Springer-Verlag, 2006 Keywords: D -Aspartic acid - D -Asp - Knee cartilage nationallicence Fisher G. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Lopez S. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Peterson K. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Goff T. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Philip I. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Gaviria R. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Lorenzo N. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Tsesarskaia M. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A. aut Amino Acids Springer-Verlag 32/1(2007-01-01), 27-30 0939-4451 32:1<27 2007 32 726 https://doi.org/10.1007/s00726-006-0353-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0353-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fisher G. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Lopez S. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Peterson K. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Goff T. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Philip I. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Gaviria R. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Lorenzo N. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 700 1- Tsesarskaia M. Department of Chemistry, Barry University, Miami Shores, Florida, U.S.A aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 27-30 0939-4451 32:1<27 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer