caa a22 4500 463185463 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00726-006-0418-7 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0418-7 Gender-based changes in cognition and emotionality in a new rat model of epilepsy [Elektronische Daten] [T. A. Doucette, C. L. Ryan, R. A. Tasker] Summary.: Epilepsy research relies heavily on animal models that mimic some, or all, of the clinical symptoms observed. We have previously described a new developmental rat model of epilepsy that demonstrates both behavioural seizures and changes in hippocampal morphology. In the current study we investigated whether these rats also show changes in cognitive performance as measured using the Morris water maze task, and emotionality as measured using the Elevated plus maze task. In the water maze, significant differences between male and female rats were found in several performance variables regardless of treatment. In addition, female but not male rats, treated neonatally with domoic acid had significant impairments in learning new platform locations in the water maze. In the elevated plus maze, a significant proportion of female rats spent more time in the open arm of the maze following prior exposure to the maze whereas this effect was not seen in male rats. We conclude that perinatal treatment with low doses of domoic acid results in significant gender-based changes in cognition and emotionality in adult rats. Springer-Verlag, 2006 Keywords: Domoic acid - Kainate - Brain development - Morris water maze - Elevated plus maze - Epilepsy nationallicence Doucette T. A. Department of Biology, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada aut Ryan C. L. Department of Psychology, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada aut Tasker R. A. Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada aut Amino Acids Springer-Verlag 32/3(2007-04-01), 317-322 0939-4451 32:3<317 2007 32 726 https://doi.org/10.1007/s00726-006-0418-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0418-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doucette T. A. Department of Biology, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada aut NATIONALLICENCE 700 1- Ryan C. L. Department of Psychology, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada aut NATIONALLICENCE 700 1- Tasker R. A. Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/3(2007-04-01), 317-322 0939-4451 32:3<317 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer