caa a22 4500 46318548X CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00726-006-0368-0 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0368-0 Comparison of taurine chloramine and taurine bromamine effects on rheumatoid arthritis synoviocytes [Elektronische Daten] [E. Kontny, M. Chorąży-Massalska, W. Rudnicka, J. Marcinkiewicz, W. Maśliński] Summary.: Fibroblast-like synoviocytes (FLS) participate in rheumatoid arthritis (RA) chronic synovitis by producing pro-inflammatory cytokines (IL-6, IL-8), growth factors (VEGF) and other inflammatory mediators (PGE2, NO). We have previously reported that Tau-Cl, generated by neutrophils, inhibits in vitro some of these pathogenic RA FLS functions. Taurine bromamine (Tau-Br) originates from eosinophils and neutrophils, and its immunoregulatory activities are poorly known. Therefore, we investigated the effects of Tau-Br on RA FLS functions and compared it to Tau-Cl anti-inflammatory action. When applied at noncytotoxic concentrations: (i) Tau-Br inhibited IL-6 and PGE2 production with potency similar to Tau-Cl (IC50 ≈ 250 µM), (ii) Tau-Br failed to affect VEGF and IL-8 synthesis, while Tau-Cl exerted inhibitory effect (IC50 ≈ 400 µM), (iii) none of these compounds affected NO generation and iNOS expression. Thus, Tau-Cl is more effective than Tau-Br in normalization of pro-inflammatory RA FLS functions. Springer-Verlag, 2006 Keywords: Taurine chloramine - Taurine bromamine - Inflammation - Rheumatoid arthritis - Synoviocytes nationallicence Kontny E. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut Chorąży-Massalska M. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut Rudnicka W. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut Marcinkiewicz J. Department of Immunology, Jagiellonian University Medical College, Cracow, Poland aut Maśliński W. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut Amino Acids Springer-Verlag 32/3(2007-04-01), 447-452 0939-4451 32:3<447 2007 32 726 https://doi.org/10.1007/s00726-006-0368-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0368-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kontny E. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut NATIONALLICENCE 700 1- Chorąży-Massalska M. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut NATIONALLICENCE 700 1- Rudnicka W. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut NATIONALLICENCE 700 1- Marcinkiewicz J. Department of Immunology, Jagiellonian University Medical College, Cracow, Poland aut NATIONALLICENCE 700 1- Maśliński W. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/3(2007-04-01), 447-452 0939-4451 32:3<447 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer