caa a22 4500 463185560 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00726-006-0414-y doi (NATIONALLICENCE)springer-10.1007/s00726-006-0414-y Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli [Elektronische Daten] [A. M. Marini, X. Jiang, X. Wu, H. Pan, Z. Guo, M. P. Mattson, N. Blondeau, A. Novelli, R. H. Lipsky] Summary.: The amino acid glutamate, the major excitatory neurotransmitter in the central nervous system, activates receptors coupled to calcium influx. Excessive activation of glutamate receptors in conditions such as severe epileptic seizures or stroke can kill neurons in a process called excitotoxicity. However, subtoxic levels of activation of the N-methyl-D-aspartate (NMDA) type of glutamate receptor elicit adaptive responses in neurons that enhance their ability to withstand more severe stress. A variety of stimuli induce adaptive responses to protect neurons. For example, sublethal ischemic episodes or a mild epileptic insult can protect neurons in a process referred to as tolerance. The molecular mechanisms that protect neurons by these different stressful stimuli are largely unknown but they share common features such as the transcription factor, nuclear factor kappa B (NF-κB), which is activated by ischemic and epileptic preconditioning as well as exposure to subtoxic NMDA concentrations. In this article, we describe stress-induced neuroprotective mechanisms highlighting the role of brain-derived neurotrophic factor (BDNF), a protein that plays a crucial role in neuronal survival and maintenance, neurogenesis and learning and memory. Springer-Verlag, 2006 Keywords: Preconditioning - Epilepsy - Neuroprotection - Hippocampus - BDNF - NF-κB nationallicence Marini A. M. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A. aut Jiang X. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A. aut Wu X. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A. aut Pan H. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A. aut Guo Z. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, U.S.A. aut Mattson M. P. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, U.S.A. aut Blondeau N. Institut de Pharmacologie Moléculaires et Cellulaires, C.N.R.S./U.N.S.A., Valbonne, France aut Novelli A. Department of Psychology, Faculty of Psychology, University of Oviedo, Oviedo, Spain aut Lipsky R. H. Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, U.S.A. aut Amino Acids Springer-Verlag 32/3(2007-04-01), 299-304 0939-4451 32:3<299 2007 32 726 https://doi.org/10.1007/s00726-006-0414-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0414-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marini A. M. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A aut NATIONALLICENCE 700 1- Jiang X. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A aut NATIONALLICENCE 700 1- Wu X. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A aut NATIONALLICENCE 700 1- Pan H. Department of Neurology and Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A aut NATIONALLICENCE 700 1- Guo Z. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, U.S.A aut NATIONALLICENCE 700 1- Mattson M. P. Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, U.S.A aut NATIONALLICENCE 700 1- Blondeau N. Institut de Pharmacologie Moléculaires et Cellulaires, C.N.R.S./U.N.S.A., Valbonne, France aut NATIONALLICENCE 700 1- Novelli A. Department of Psychology, Faculty of Psychology, University of Oviedo, Oviedo, Spain aut NATIONALLICENCE 700 1- Lipsky R. H. Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, U.S.A aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/3(2007-04-01), 299-304 0939-4451 32:3<299 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer