caa a22 4500 463185579 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00726-007-0509-0 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0509-0 Nuclear/cytoplasmic localization of Akt activity in the cell cycle [Elektronische Daten] [M. Rosner, M. Hanneder, A. Freilinger, M. Hengstschläger] Summary.: The serine/threonine protein kinase Akt (also known as PKB) is a proto-oncogene and one of the most frequently hyperactivated kinases in human cancer. Its activation downstream of growth-factor-stimulated phosphatidylinositide-3′-OH kinase activity plays a role in the control of cell cycle, cell growth, apoptosis and cell energy metabolism. Akt phosphorylates some thousand downstream substrates, including typical cytoplasmic as well as nuclear proteins. Accordingly, it is not surprising that Akt activity can be found in both, the cytoplasm and the nucleus. Here we report the cell cycle regulation of nuclear and cytoplasmic Akt activity in mammalian cells. These data provide new insights into the regulation of Akt activity and have implications for future studies on the regulation of the wide variety of different nuclear and cytoplasmic Akt substrates. Springer-Verlag, 2007 Keywords: Akt - Cell cycle - Nucleus - Cytoplasm nationallicence Rosner M. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut Hanneder M. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut Freilinger A. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut Hengstschläger M. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut Amino Acids Springer-Verlag 32/3(2007-04-01), 341-345 0939-4451 32:3<341 2007 32 726 https://doi.org/10.1007/s00726-007-0509-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0509-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosner M. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Hanneder M. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Freilinger A. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Hengstschläger M. Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/3(2007-04-01), 341-345 0939-4451 32:3<341 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer