caa a22 4500 463185617 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00726-006-0380-4 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0380-4 Taurine promotes connective tissue growth factor (CTGF) expression in osteoblasts through the ERK signal pathway [Elektronische Daten] [L.-Q. Yuan, Y. Lu, X.-H. Luo, H. Xie, X.-P. Wu, E.-Y. Liao] Summary.: Taurine is found in bone tissue, but its function in skeletal tissue is not fully understood. The present study was undertaken to investigate regulation of gene expression of connective tissue growth factor (CTGF), and the roles of mitogen-activated protein kinases (MAPKs) in murine osteoblast MC3T3-E1 cells treated with taurine. Western blot analysis showed taurine stimulated CTGF protein secretion in a dose- and time-dependent manner. Taurine induced activation of extracellular signal-regulated kinase (ERK), but not p38 and c-jun N-terminal Kinase (JNK), in osteoblasts. Furthermore, pretreatment of osteoblasts with the ERK inhibitor PD98059 abolished the taurine-induced CTGF production. These data indicate that taurine induces CTGF secretion in MC3T3-E1 cells mediated by the ERK pathway, and suggest that osteoblasts are direct targets of taurine. Springer-Verlag, 2006 Keywords: Taurine - Osteoblast - Connective tissue growth factor - Mitogen-activated protein kinase nationallicence Yuan L.-Q Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut Lu Y. Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut Luo X.-H Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut Xie H. Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut Wu X.-P Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut Liao E.-Y Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut Amino Acids Springer-Verlag 32/3(2007-04-01), 425-430 0939-4451 32:3<425 2007 32 726 https://doi.org/10.1007/s00726-006-0380-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0380-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yuan L.-Q Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Lu Y. Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Luo X.-H Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Xie H. Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Wu X.-P Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Liao E.-Y Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/3(2007-04-01), 425-430 0939-4451 32:3<425 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer