caa a22 4500 463185633 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00726-006-0383-1 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0383-1 The effect of taurine on renal ischemia/reperfusion injury [Elektronische Daten] [G. Guz, E. Oz, N. Lortlar, N. N. Ulusu, N. Nurlu, B. Demirogullari, S. Omeroglu, S. Sert, C. Karasu] Summary.: Ischemia-reperfusion (I/R) injury is one of the most common causes of renal dysfunction. Taurine is an endogenous antioxidant and a membrane-stabilizing, intracellular, free beta-amino acid. It has been demonstrated to have protective effects against I/R injuries to tissues other than kidney. The aim of this study was to determine whether taurine has a beneficial role in renal I/R injury. Forty Wistar-Albino rats were allocated into four groups as follows: sham, taurine, I/R, and I/R + taurine. Taurine 7.5 mg/kg was given intra-peritoneally to rats in the groups taurine and I/R + taurine. Renal I/R was achieved by occluding the renal arteries bilaterally for 40 min, followed by 6 h of reperfusion. Immediately thereafter, blood was drawn and tissue samples were harvested to measure 1) serum levels of BUN and creatinine; 2) serum and/or tissue levels of malondialdehyde (MDA), glutathione (GSH), glucose 6-phosphate dehydrogenase (G-6PD), 6-phosphogluconate dehydrogenase (6-PGD) and glutathione reductase (GSH-red); 3) renal morphology; and 4) immunohistochemical staining for P-selectin. Taurine administration reduced I/R-induced increases in serum BUN and creatinine, and serum and tissue MDA levels (p < 0.05). Additionally, taurine lessened the reductions in serum and tissue glutathione levels secondary to I/R (p < 0.05). Taurine also attenuated histopathologic evidence of renal injury, and reduced I/R-induced P-selectin immunoreactivity (p < 0.05). Overall, then, taurine administration appears to reduce the injurious effects of I/R on kidney. Springer-Verlag, 2006 Keywords: Taurine - Ischemia - Reperfusion - Kidney - Malondialdehyde and glutathione nationallicence Guz G. Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey aut Oz E. Department of Physiology, Gazi University Faculty of Medicine, Ankara, Turkey aut Lortlar N. Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey aut Ulusu N. N. Department of Biochemistry, Hacettpe University Faculty of Medicine, Ankara, Turkey aut Nurlu N. Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey aut Demirogullari B. Department of Pediatric Surgery, Gazi University Faculty of Medicine, Ankara, Turkey aut Omeroglu S. Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey aut Sert S. Department of Transplantation Surgery, Gazi University Faculty of Medicine, Ankara, Turkey aut Karasu C. Department of Medical Pharmacology, Gazi University Faculty of Medicine, Ankara, Turkey aut Amino Acids Springer-Verlag 32/3(2007-04-01), 405-411 0939-4451 32:3<405 2007 32 726 https://doi.org/10.1007/s00726-006-0383-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0383-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guz G. Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Oz E. Department of Physiology, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Lortlar N. Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Ulusu N. N. Department of Biochemistry, Hacettpe University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Nurlu N. Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Demirogullari B. Department of Pediatric Surgery, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Omeroglu S. Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Sert S. Department of Transplantation Surgery, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 700 1- Karasu C. Department of Medical Pharmacology, Gazi University Faculty of Medicine, Ankara, Turkey aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/3(2007-04-01), 405-411 0939-4451 32:3<405 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer