caa a22 4500 463185706 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00726-006-0433-8 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0433-8 Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patients [Elektronische Daten] [M. Piroddi, I. Depunzio, V. Calabrese, C. Mancuso, C. M. Aisa, L. Binaglia, A. Minelli, A. D. Butterfield, F. Galli] Summary.: End stage renal disease (ESRD) patients accumulate blood hallmarks of protein glycation and oxidation. It is now well established that these protein damage products may represent a heterogeneous class of uremic toxins with pro-inflammatory and pro-oxidant properties. These toxins could be directly involved in the pathogenesis of the inflammatory syndrome and vascular complications, which are mainly sustained by the uremic state and bioincompatibility of dialysis therapy. A key underlying event in the toxicity of these proteinaceous solutes has been identified in scavenger receptor-dependent recognition and elimination by inflammatory and endothelial cells, which once activated generate further and even more pronounced protein injuries by a self-feeding mechanism based on inflammation and oxidative stress-derived events. This review examines the literature and provides original information on the techniques for investigating proteinaceous pro-inflammatory toxins. We have also evaluated therapeutic - either pharmacological or dialytic - strategies proposed to alleviate the accumulation of these toxins and to constrain the inflammatory and oxidative burden of ESRD. Springer-Verlag, 2007 Keywords: Protein damage - Oxidation - Glycation - AGEs - Inflammation - Reactive oxygen species - Nitric oxide - Uremia - Dialysis - Proteomics nationallicence Piroddi M. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut Depunzio I. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut Calabrese V. Department of Chemistry, Section of Biochemistry and Molecular Biology, University of Catania, Catania, Italy aut Mancuso C. Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy aut Aisa C. M. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut Binaglia L. Department of Internal Medicine, Section of Biochemistry, University of Perugia, Perugia, Italy aut Minelli A. Department of Experimental Medicine and Biochemical Sciences, Section of Cellular Biochemistry, University of Perugia, Perugia, Italy aut Butterfield A. D. Center of Membrane Sciences, and Sanders-Brown Center on Aging, Department of Chemistry, University of Kentucky, Lexington, KY, U.S.A. aut Galli F. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut Amino Acids Springer-Verlag 32/4(2007-05-01), 573-592 0939-4451 32:4<573 2007 32 726 https://doi.org/10.1007/s00726-006-0433-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0433-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piroddi M. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Depunzio I. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Calabrese V. Department of Chemistry, Section of Biochemistry and Molecular Biology, University of Catania, Catania, Italy aut NATIONALLICENCE 700 1- Mancuso C. Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy aut NATIONALLICENCE 700 1- Aisa C. M. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Binaglia L. Department of Internal Medicine, Section of Biochemistry, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Minelli A. Department of Experimental Medicine and Biochemical Sciences, Section of Cellular Biochemistry, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Butterfield A. D. Center of Membrane Sciences, and Sanders-Brown Center on Aging, Department of Chemistry, University of Kentucky, Lexington, KY, U.S.A aut NATIONALLICENCE 700 1- Galli F. Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/4(2007-05-01), 573-592 0939-4451 32:4<573 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer