caa a22 4500 463185757 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00726-006-0428-5 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0428-5 The nuclear proteasome and the degradation of oxidatively damaged proteins [Elektronische Daten] [P. Voss, T. Grune] Summary.: The accumulation of oxidized proteins is known to be linked to some severe neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease. Furthermore, the aging process is also accompanied by an ongoing aggregation of misfolded and damaged proteins. Therefore, mammalian cells have developed potent degradation systems, which selectively degrade damaged and misfolded proteins. The proteasomal system is largely responsible for the removal of oxidatively damaged proteins form the cellular environment. Not only cytosolic proteins are prone to oxidative stress, also nuclear proteins are readily oxidized. The nuclear proteasomal system is responsible for the degradation of these proteins. This review is focused on the specific degradation of oxidized nuclear proteins, the role of the proteasome in this process and the regulation of the nuclear proteasomal system under oxidative conditions. Springer-Verlag, 2006 Keywords: Protein oxidation - Protein degradation - Proteasome - Nucleus - Histone - PARP nationallicence AD : Alzheimer's disease nationallicence ADP : adenosinediphosphate nationallicence AGE : advanced glycosilation end products nationallicence ATP : adenosinetriphosphate nationallicence DNA : desoxyribonucleic acid nationallicence EGF : epidermal growth factor nationallicence ER : endoplasmic reticulum nationallicence G6PD : glucose-6-phosphate dehydrogenase nationallicence GAPDH : glyceraldehyde-3-phosphate dehydrogenase nationallicence HD : Huntington's disease nationallicence HNE : 4-hydroxynonenal nationallicence IFγ : interferon γ nationallicence MDA : malondialdehyde nationallicence MHC-I : major histocompatibility complex class I nationallicence NAD+ : nicotinamide adenosine dinucleotide nationallicence NLS : nuclear localization signal nationallicence pADPR : poly-(ADP-ribose) nationallicence PARP : poly-(ADP-ribose) polymerase nationallicence PD : Parkinson's disease nationallicence RNS : reactive nitrogen species nationallicence ROS : reactive oxygen species nationallicence Voss P. Research Institute of Environmental Medicine, Heinrich Heine University, Duesseldorf, Germany aut Grune T. Research Institute of Environmental Medicine, Heinrich Heine University, Duesseldorf, Germany aut Amino Acids Springer-Verlag 32/4(2007-05-01), 527-534 0939-4451 32:4<527 2007 32 726 https://doi.org/10.1007/s00726-006-0428-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0428-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Voss P. Research Institute of Environmental Medicine, Heinrich Heine University, Duesseldorf, Germany aut NATIONALLICENCE 700 1- Grune T. Research Institute of Environmental Medicine, Heinrich Heine University, Duesseldorf, Germany aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/4(2007-05-01), 527-534 0939-4451 32:4<527 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer