caa a22 4500 463185765 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00726-006-0431-x doi (NATIONALLICENCE)springer-10.1007/s00726-006-0431-x Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease [Elektronische Daten] [M. C. Polidori, H. R. Griffiths, E. Mariani, P. Mecocci] Summary.: The pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, has been linked to a condition of oxidative and nitrosative stress, arising from the imbalance between increased reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and antioxidant defences or efficiency of repair or removal systems. The effects of free radicals are expressed by the accumulation of oxidative damage to biomolecules: nucleic acids, lipids and proteins. In this review we focused our attention on the large body of evidence of oxidative damage to protein in Alzheimer's disease brain and peripheral cells as well as in their role in signalling pathways. The progress in the understanding of the molecular alterations underlying Alzheimer's disease will be useful in developing successful preventive and therapeutic strategies, since available drugs can only temporarily stabilize the disease, but are not able to block the neurodegenerative process. Springer-Verlag, 2007 Keywords: Alzheimer's disease - Aging - Oxidative stress - Nitrosative stress - Protein nationallicence Polidori M. C. Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, Düsseldorf, Germany aut Griffiths H. R. Life and Health Sciences, Aston University, Aston Triangle, Birmingham, U.K. aut Mariani E. Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy aut Mecocci P. Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy aut Amino Acids Springer-Verlag 32/4(2007-05-01), 553-559 0939-4451 32:4<553 2007 32 726 https://doi.org/10.1007/s00726-006-0431-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0431-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Polidori M. C. Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Griffiths H. R. Life and Health Sciences, Aston University, Aston Triangle, Birmingham, U.K aut NATIONALLICENCE 700 1- Mariani E. Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy aut NATIONALLICENCE 700 1- Mecocci P. Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/4(2007-05-01), 553-559 0939-4451 32:4<553 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer