caa a22 4500 463185773 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00726-006-0448-1 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0448-1 Protein-carbonyl accumulation in the non-replicative senescence of the methionine sulfoxide reductase A ( msrA ) knockout yeast strain [Elektronische Daten] [D. Oien, J. Moskovitz] Summary.: The major enzyme of the methionine sulfoxide reductase (Msr) system is MsrA. Senescing msrA knockout mother yeast cells accumulated significant amounts of protein-carbonyl both at 5 generation-old (young) and 21 generation-old (old) cultures, while the control mother cells showed significant levels of protein-carbonyl mainly in the old culture. The Msr activities of both yeast strains declined with age and exposure of cells to H2O2 caused an accumulation of protein-carbonyl especially in the msrA knockout strain. It is suggested that a compromised MsrA activity may serve as a marker for non-replicative aging. Springer-Verlag, 2006 Keywords: Oxidative-stress - Non-replicative senescence - Post-translation modification nationallicence Oien D. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, U.S.A. aut Moskovitz J. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, U.S.A. aut Amino Acids Springer-Verlag 32/4(2007-05-01), 603-606 0939-4451 32:4<603 2007 32 726 https://doi.org/10.1007/s00726-006-0448-1 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0448-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oien D. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, U.S.A aut NATIONALLICENCE 700 1- Moskovitz J. Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, U.S.A aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/4(2007-05-01), 603-606 0939-4451 32:4<603 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer