caa a22 4500 463185803 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00726-006-0426-7 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0426-7 Lipid nitration and formation of lipid-protein adducts: biological insights [Elektronische Daten] [A. Trostchansky, H. Rubbo] Summary.: Lipid-protein adducts are formed during oxidative and nitrative stress conditions associated with increasing lipid and protein oxidation and nitration. The focus of this review is the analysis of interactions between oxidative-modified lipids and proteins and how lipid nitration can modulate lipid-protein adducts formation. For this, two biologically-relevant models will be analysed: a) human low density lipoprotein, whose oxidation is involved in the early steps of atherogenesis, and b) α-synuclein/lipid membranes system, where lipid-protein adducts are being associated with the develop of Parkinson disease and other synucleinopathies. Springer-Verlag, 2006 Keywords: Lipid oxidation - Nitrated lipid - Peroxynitrite - Lipid-protein adduct - Nitric oxide - Free radicals - α-Synuclein - Low density lipoprotein nationallicence Trostchansky A. Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay aut Rubbo H. Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay aut Amino Acids Springer-Verlag 32/4(2007-05-01), 517-522 0939-4451 32:4<517 2007 32 726 https://doi.org/10.1007/s00726-006-0426-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0426-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trostchansky A. Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay aut NATIONALLICENCE 700 1- Rubbo H. Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/4(2007-05-01), 517-522 0939-4451 32:4<517 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer