caa a22 4500 463185811 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00726-007-0494-3 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0494-3 Absorption, tissue distribution, metabolism and elimination of taurine given orally to rats [Elektronische Daten] [D. W. Sved, J. L. Godsey, S. L. Ledyard, A. P. Mahoney, P. L. Stetson, S. Ho, N. R. Myers, P. Resnis, A. G. Renwick] Summary.: Three biodisposition studies with taurine were performed in male and female adult rats at dosages of 30 and 300 mg/kg. A single oral dose of 14C-taurine was rapidly absorbed, distributed to tissues and excreted unchanged in urine. Elimination of radioactivity from intracellular pools was slow. Pre-treatment of animals for 14 days with unlabelled taurine did not significantly affect the fate of 14C-taurine. At the higher dose there was more extensive excretion combined with a lower percentage of the dose in the carcass, indicating the possibility of saturation of the tubular reabsorption mechanism for taurine. Daily administration of unlabelled taurine for 14 days did not result in an increase in total taurine in the brain. The data indicate that exogenous taurine rapidly equilibrates with endogenous body pools and that any excess is rapidly eliminated by the kidneys. Springer-Verlag, 2007 Keywords: Taurine - Toxicokinetics - Absorption - Tissue distribution - Elimination nationallicence Sved D. W. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Godsey J. L. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Ledyard S. L. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Mahoney A. P. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Stetson P. L. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Ho S. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Myers N. R. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Resnis P. WIL Research Laboratories, LLC, Ashland, OH, U.S.A. aut Renwick A. G. School of Medicine, University of Southampton, Southampton, U.K. aut Amino Acids Springer-Verlag 32/4(2007-05-01), 459-466 0939-4451 32:4<459 2007 32 726 https://doi.org/10.1007/s00726-007-0494-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0494-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sved D. W. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Godsey J. L. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Ledyard S. L. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Mahoney A. P. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Stetson P. L. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Ho S. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Myers N. R. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Resnis P. WIL Research Laboratories, LLC, Ashland, OH, U.S.A aut NATIONALLICENCE 700 1- Renwick A. G. School of Medicine, University of Southampton, Southampton, U.K aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/4(2007-05-01), 459-466 0939-4451 32:4<459 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer