caa a22 4500 463185900 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00726-006-0369-z doi (NATIONALLICENCE)springer-10.1007/s00726-006-0369-z Felinine stability in the presence of selected urine compounds [Elektronische Daten] [S. M. Rutherfurd, T. M. Kitson, A. D. Woolhouse, M. C. McGrath, W. H. Hendriks] Summary.: The stability of felinine, an amino acid present in feline urine, was investigated. Synthetic felinine was unstable in the urine of a selection of mammals. Felinine was found to stable in feline urine in which urea had been degraded. Synthetic felinine was found to react specifically with urea and did not react with urea analogues such as biuret or thiourea or other nucleophilic compounds such as ammonia which is more nucleophilic or acetamide and water which are less nucleophilic than urea. The reaction of urea and felinine was independent of pH over the range of 3-10. Urea did not react with N-acetyl-felinine suggesting a felinine N-terminal interaction with urea. Mass spectral analysis of the reaction products showed the presence of carbamylated felinine and fragmentation ions derived from carbamyl-felinine. The physiological relevance of felinine carbamylation is yet to be determined. Springer-Verlag, 2006 Keywords: Felinine - Urea - Cats - Urine - Carbamylation - Smell nationallicence Rutherfurd S. M. Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand aut Kitson T. M. Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand aut Woolhouse A. D. Industrial Research Ltd., Lower Hutt, New Zealand aut McGrath M. C. Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand aut Hendriks W. H. Nutrition Group, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands aut Amino Acids Springer-Verlag 32/2(2007-02-01), 235-242 0939-4451 32:2<235 2007 32 726 https://doi.org/10.1007/s00726-006-0369-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0369-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rutherfurd S. M. Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand aut NATIONALLICENCE 700 1- Kitson T. M. Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand aut NATIONALLICENCE 700 1- Woolhouse A. D. Industrial Research Ltd., Lower Hutt, New Zealand aut NATIONALLICENCE 700 1- McGrath M. C. Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand aut NATIONALLICENCE 700 1- Hendriks W. H. Nutrition Group, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/2(2007-02-01), 235-242 0939-4451 32:2<235 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer