caa a22 4500 463185919 CHVBK 20180406164852.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00726-006-0362-6 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0362-6 The role of growth hormone and amino acids on brain protein synthesis in aged rats given proteins of different quantity and quality [Elektronische Daten] [M. Ohsumi, X. Shi, T. Tuchiya, K. Tujioka, S. Lyou, K. Hayase, H. Yokogoshi] Summary.: The purpose of the present study was to determine whether the regulation of brain protein synthesis was mediated through changes in the plasma concentrations of insulin and growth hormone (GH), and whether the concentrations of amino acids in the brain and plasma regulate the brain protein synthesis when the quantity and quality of dietary protein is manipulated. Two experiments were done on three groups of aged rats given diets containing 20% casein, 5% casein or 0% casein (Experiment 1), and 20% casein, 20% gluten, or 20% gelatin (Experiment 2) for 1 d (only one 5-h period) after all rats were fed the 20% casein diet for 10 d (only 5-h feeding per day). The aggregation of brain ribosomes, the concentration in plasma GH, and the branched chain amino acids in the plasma and cerebral cortex declined with a decrease of quantity and quality of dietary protein. The concentration of plasma insulin did not differ among groups. The results suggest that the ingestion of a higher quantity and quality of dietary protein increases the concentrations of GH and several amino acids in aged rats, and that the concentrations of GH and amino acids are at least partly related to the mechanism by which the dietary protein affects brain protein synthesis in aged rats. Springer-Verlag, 2006 Keywords: Dietary protein - Brain protein synthesis - Amino acids - Insulin - Growth hormone - Rats nationallicence GH : growth hormone nationallicence Ohsumi M. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut Shi X. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut Tuchiya T. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut Tujioka K. Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Yada, Shizuoka, Japan aut Lyou S. Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Yada, Shizuoka, Japan aut Hayase K. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut Yokogoshi H. Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Yada, Shizuoka, Japan aut Amino Acids Springer-Verlag 32/2(2007-02-01), 247-253 0939-4451 32:2<247 2007 32 726 https://doi.org/10.1007/s00726-006-0362-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0362-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohsumi M. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut NATIONALLICENCE 700 1- Shi X. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut NATIONALLICENCE 700 1- Tuchiya T. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut NATIONALLICENCE 700 1- Tujioka K. Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Yada, Shizuoka, Japan aut NATIONALLICENCE 700 1- Lyou S. Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Yada, Shizuoka, Japan aut NATIONALLICENCE 700 1- Hayase K. Department of Home Economics, Aichi University of Education, Kariya, Aichi, Japan aut NATIONALLICENCE 700 1- Yokogoshi H. Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, COE Program in the 21st Century, The University of Shizuoka, Yada, Shizuoka, Japan aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/2(2007-02-01), 247-253 0939-4451 32:2<247 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer