caa a22 4500 463185943 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00726-006-0364-4 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0364-4 Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity [Elektronische Daten] [C. A. Hill, R. C. Harris, H. J. Kim, B. D. Harris, C. Sale, L. H. Boobis, C. K. Kim, J. A. Wise] Summary.: Muscle carnosine synthesis is limited by the availability of β-alanine. Thirteen male subjects were supplemented with β-alanine (CarnoSyn™) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine total work done (TWD) at 110% (CCT110%) of their maximum power (Wmax). Twelve matched subjects received a placebo. Eleven of these completed the CCT110% at 0 and 4 wks, and 8, 10 wks. Muscle biopsies were obtained from 5 of the 8 and one additional subject. Muscle carnosine was significantly increased by +58.8% and +80.1% after 4 and 10 wks β-alanine supplementation. Carnosine, initially 1.71 times higher in type IIa fibres, increased equally in both type I and IIa fibres. No increase was seen in control subjects. Taurine was unchanged by 10 wks of supplementation. 4 wks β-alanine supplementation resulted in a significant increase in TWD (+13.0%); with a further +3.2% increase at 10 wks. TWD was unchanged at 4 and 10 wks in the control subjects. The increase in TWD with supplementation followed the increase in muscle carnosine. Springer-Verlag, 2006 Keywords: β-alanine - Muscle - Carnosine - Taurine - Exercise - Cycle performance nationallicence Hill C. A. School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, U.K. aut Harris R. C. School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, U.K. aut Kim H. J. Human Exercise Physiology, Korea National Sport University, Seoul, Korea aut Harris B. D. School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, U.K. aut Sale C. Centre for Human Sciences, QinetiQ, Farnborough, U.K. aut Boobis L. H. Sunderland Royal Hospital, Sunderland, U.K. aut Kim C. K. Human Exercise Physiology, Korea National Sport University, Seoul, Korea aut Wise J. A. Natural Alternatives International, San Marcos, CA, U.S.A. aut Amino Acids Springer-Verlag 32/2(2007-02-01), 225-233 0939-4451 32:2<225 2007 32 726 https://doi.org/10.1007/s00726-006-0364-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0364-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hill C. A. School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, U.K aut NATIONALLICENCE 700 1- Harris R. C. School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, U.K aut NATIONALLICENCE 700 1- Kim H. J. Human Exercise Physiology, Korea National Sport University, Seoul, Korea aut NATIONALLICENCE 700 1- Harris B. D. School of Sports, Exercise & Health Sciences, University of Chichester, Chichester, U.K aut NATIONALLICENCE 700 1- Sale C. Centre for Human Sciences, QinetiQ, Farnborough, U.K aut NATIONALLICENCE 700 1- Boobis L. H. Sunderland Royal Hospital, Sunderland, U.K aut NATIONALLICENCE 700 1- Kim C. K. Human Exercise Physiology, Korea National Sport University, Seoul, Korea aut NATIONALLICENCE 700 1- Wise J. A. Natural Alternatives International, San Marcos, CA, U.S.A aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/2(2007-02-01), 225-233 0939-4451 32:2<225 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer