caa a22 4500 463185994 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00726-006-0317-y doi (NATIONALLICENCE)springer-10.1007/s00726-006-0317-y An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats [Elektronische Daten] [K. Ossowska, J. Konieczny, J. Wardas, M. Pietraszek, K. Kuter, S. Wolfarth, A. Pilc] Summary.: Several data indicate that inhibition of glutamatergic transmission may be important to alleviate of parkinsonian symptoms. Therefore, the aim of the present paper is to review recent studies on the search for putative antiparkinsonian-like effects of mGluR ligands and their brain targets. In order to inhibit glutamatergic transmission, the group I mGluRs (mGluR1 and mGluR5) were blocked, and group II (mGluR2/3) or III (mGluR4/7/8) mGluRs were activated. Systemic or intrastriatal administration of group I mGluR antagonists (mGluR5 - MPEP, MTEP; mGluR1 - AIDA) was found to inhibit parkinsonian-like symptoms (catalepsy, muscle rigidity) in rats. MPEP administered systemically and mGluR1 antagonists (AIDA, CPCCOEt, LY367385) injected intrastriatally reversed also the haloperidol-increased proenkephalin (PENK) mRNA expression in the striatopallidal pathway. Similarly, ACPT-1, a group III mGluR agonist, administered into the striatum, globus pallidus or substantia nigra inhibited the catalepsy. Intrastriatal injection of this compound reduced the striatal PENK expression induced by haloperidol. In contrast, a group II mGluR agonist (2R,4R-APDC) administered intrastriatally reduced neither PENK expression nor the above-mentioned parkinsonian-like symptoms. Moreover, a mixed mGluR8 agonist/AMPA antagonist, (R,S)-3,4-DCPG, administered systemically evoked catalepsy and enhanced both the catalepsy and PENK expression induced by haloperidol. The results reviewed in this article seem to indicate that group I mGluR antagonists or some agonists of group III may possess antiparkinsonian properties, and point at the striatopallidal pathway as a potential target of therapeutic intervention. Springer-Verlag, 2006 Keywords: Metabotropic glutamate receptors - Antiparkinsonian-like effects - Striatum - Striatopallidal pathway - Proenkephalin mRNA nationallicence Ossowska K. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Konieczny J. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Wardas J. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Pietraszek M. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Kuter K. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Wolfarth S. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Pilc A. Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut Amino Acids Springer-Verlag 32/2(2007-02-01), 179-188 0939-4451 32:2<179 2007 32 726 https://doi.org/10.1007/s00726-006-0317-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0317-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ossowska K. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Konieczny J. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Wardas J. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Pietraszek M. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Kuter K. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Wolfarth S. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 700 1- Pilc A. Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/2(2007-02-01), 179-188 0939-4451 32:2<179 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer