caa a22 4500 463186133 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00726-007-0542-z doi (NATIONALLICENCE)springer-10.1007/s00726-007-0542-z Strategies for comprehensive analysis of amino acid biomarkers of oxidative stress [Elektronische Daten] [A. S. Ptolemy, R. Lee, P. Britz-McKibbin] Summary.: Despite the wide interest in using modified amino acids as putative biomarkers of oxidative stress, many issues remain as to their overall reliability for early detection and diagnosis of diseases. In contrast to conventional single biomarker studies, comprehensive analysis of biomarkers offers an unbiased strategy for global assessment of modified amino acid metabolism due to reactive oxygen and nitrogen species. This review examines recent analytical techniques amenable for analysis of modified amino acids in biological samples reported during 2003-2007. Particular attention is devoted to the need for validated methods applicable to high-throughput analysis of multiple amino acid biomarkers, as well as consideration of sample pretreatment protocols on artifact formation for improved clinical relevance. Springer-Verlag, 2007 Keywords: Oxidative stress - Modified amino acids - Analytical techniques - Comprehensive analysis - Multiple biomarkers nationallicence Ptolemy A. S. Department of Chemistry, McMaster University, Hamilton, Ontario, Canada aut Lee R. Department of Chemistry, McMaster University, Hamilton, Ontario, Canada aut Britz-McKibbin P. Department of Chemistry, McMaster University, Hamilton, Ontario, Canada aut Amino Acids Springer-Verlag 33/1(2007-07-01), 3-18 0939-4451 33:1<3 2007 33 726 https://doi.org/10.1007/s00726-007-0542-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0542-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ptolemy A. S. Department of Chemistry, McMaster University, Hamilton, Ontario, Canada aut NATIONALLICENCE 700 1- Lee R. Department of Chemistry, McMaster University, Hamilton, Ontario, Canada aut NATIONALLICENCE 700 1- Britz-McKibbin P. Department of Chemistry, McMaster University, Hamilton, Ontario, Canada aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/1(2007-07-01), 3-18 0939-4451 33:1<3 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer