caa a22 4500 463186141 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00726-006-0397-8 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0397-8 Blood amino acids concentration during insulin induced hypoglycemia in rats: the role of alanine and glutamine in glucose recovery [Elektronische Daten] [R. F. Garcia, V. A. F. G. Gazola, H. C. Barrena, E. M. Hartmann, J. Berti, M. H. Toyama, A. C. Boschero, E. M. Carneiro, F. C. Manso, R. B. Bazotte] Summary.: Our purpose was to determine the blood amino acid concentration during insulin induced hypoglycemia (IIH) and examine if the administration of alanine or glutamine could help glycemia recovery in fasted rats. IIH was obtained by an intraperitoneal injection of regular insulin (1.0 U/kg). The blood levels of the majority of amino acids, including alanine and glutamine were decreased (P < 0.05) during IIH and this change correlates well with the duration than the intensity of hypoglycemia. On the other hand, the oral and intraperitoneal administration of alanine (100 mg/kg) or glutamine (100 mg/kg) accelerates glucose recovery. This effect was partly at least consequence of the increased capacity of the livers from IIH group to produce glucose from alanine and glutamine. It was concluded that the blood amino acids availability during IIH, particularly alanine and glutamine, play a pivotal role in recovery from hypoglycemia. Springer-Verlag, 2006 Keywords: Amino acids - Alanine - Glutamine - Gluconeogenesis - Hypoglycemia - Insulin nationallicence Garcia R. F. Department of Morphophysiological Sciences, State University of Maringá, Paraná, Brazil aut Gazola V. A. F. G. Department of Morphophysiological Sciences, State University of Maringá, Paraná, Brazil aut Barrena H. C. CNPq fellowship, State University of Maringá, Paraná, Brazil aut Hartmann E. M. CNPq fellowship, State University of Maringá, Paraná, Brazil aut Berti J. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut Toyama M. H. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut Boschero A. C. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut Carneiro E. M. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut Manso F. C. Department of Pharmacy and Pharmacology, State University of Maringá, Paraná, Brazil aut Bazotte R. B. Department of Pharmacy and Pharmacology, State University of Maringá, Paraná, Brazil aut Amino Acids Springer-Verlag 33/1(2007-07-01), 151-155 0939-4451 33:1<151 2007 33 726 https://doi.org/10.1007/s00726-006-0397-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0397-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garcia R. F. Department of Morphophysiological Sciences, State University of Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Gazola V. A. F. G. Department of Morphophysiological Sciences, State University of Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Barrena H. C. CNPq fellowship, State University of Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Hartmann E. M. CNPq fellowship, State University of Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Berti J. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut NATIONALLICENCE 700 1- Toyama M. H. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut NATIONALLICENCE 700 1- Boschero A. C. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut NATIONALLICENCE 700 1- Carneiro E. M. Department of Physiology and Biophysics, UNICAMP, São Paulo, Brazil aut NATIONALLICENCE 700 1- Manso F. C. Department of Pharmacy and Pharmacology, State University of Maringá, Paraná, Brazil aut NATIONALLICENCE 700 1- Bazotte R. B. Department of Pharmacy and Pharmacology, State University of Maringá, Paraná, Brazil aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/1(2007-07-01), 151-155 0939-4451 33:1<151 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer