caa a22 4500 46318615X CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00726-006-0454-3 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0454-3 A dynamic model for the p53 stress response networks under ion radiation [Elektronische Daten] [J.-P. Qi, S.-H. Shao, D.-D. Li, G.-P. Zhou] Summary.: P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways. To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular level, a dynamic model for the p53 stress response networks is proposed. The model can be successfully used to simulate the dynamic processes of generating the double-strand breaks (DSBs) and their repairing, ataxia telangiectasia mutated (ATM) activation, as well as the oscillations occurring in the p53-MDM2 feedback loop. Springer-Verlag, 2006 Keywords: Cellular networks - p53 - MDM2 - IR - DNA damage - Oscillations nationallicence Qi J.-P Bio-Informatics Research Center, Donghua University, Shanghai, China aut Shao S.-H Bio-Informatics Research Center, Donghua University, Shanghai, China aut Li D.-D Bio-Informatics Research Center, Donghua University, Shanghai, China aut Zhou G.-P Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, U.S.A. aut Amino Acids Springer-Verlag 33/1(2007-07-01), 75-83 0939-4451 33:1<75 2007 33 726 https://doi.org/10.1007/s00726-006-0454-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0454-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qi J.-P Bio-Informatics Research Center, Donghua University, Shanghai, China aut NATIONALLICENCE 700 1- Shao S.-H Bio-Informatics Research Center, Donghua University, Shanghai, China aut NATIONALLICENCE 700 1- Li D.-D Bio-Informatics Research Center, Donghua University, Shanghai, China aut NATIONALLICENCE 700 1- Zhou G.-P Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, U.S.A aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/1(2007-07-01), 75-83 0939-4451 33:1<75 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer