caa a22 4500 463186206 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00726-006-0420-0 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0420-0 A unified hypothesis of coeliac disease with implications for management of patients [Elektronische Daten] [H. J. Cornell, T. Stelmasiak] Summary.: This mini-review presents the research carried out within the context of two of the main hypotheses of the aetiology of coeliac disease. The enzymopathic hypothesis of the disease has been placed clearly as the underlying deficiency causing increased levels of toxic peptides, while the immunological hypothesis has been implicated in the pathogenesis of the disorder as the result of the action of undigested peptides in the small intestine. As a consequence, we are proposing a unified hypothesis of coeliac disease, which takes into account the actions of these undigested peptides through their direct cytotoxicity and their immunoactivity. At the same time, work aimed at defining some of these biologically active peptides, which could be said to be involved in the aetiopathogenesis of coeliac disease, will be reported. The review also focusses on the use of enzyme therapy for management of the disease, which when used in conjunction with the gluten-free diet, offers a safeguard against damage to the small intestine caused by small amounts of gluten. Springer-Verlag, 2006 Keywords: Coeliac disease - Enzyme therapy - Gliadins - Gluten - Disease mechanisms - Peptidases nationallicence Cornell H. J. School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia aut Stelmasiak T. Glutagen Pty Ltd, Maribyrnong, Victoria, Australia aut Amino Acids Springer-Verlag 33/1(2007-07-01), 43-49 0939-4451 33:1<43 2007 33 726 https://doi.org/10.1007/s00726-006-0420-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0420-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cornell H. J. School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia aut NATIONALLICENCE 700 1- Stelmasiak T. Glutagen Pty Ltd, Maribyrnong, Victoria, Australia aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/1(2007-07-01), 43-49 0939-4451 33:1<43 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer