caa a22 4500 463186214 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00726-006-0412-0 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0412-0 Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-deficient condition [Elektronische Daten] [N. Shikata, Y. Maki, Y. Noguchi, M. Mori, T. Hanai, M. Takahashi, M. Okamoto] Summary.: The concentrations of free amino acids in plasma change coordinately and their profiles show distinctive features in various physiological conditions; however, their behavior can not always be explained by the conventional flow-based metabolic pathway network. In this study, we have revealed the interrelatedness of the plasma amino acids and inferred their network structure with threshold-test analysis and multilevel-digraph analysis methods using the plasma samples of rats which are fed diet deficient in single essential amino acid. In the inferred network, we could draw some interesting interrelations between plasma amino acids as follows: 1) Lysine is located at the top control level and has effects on almost all of the other plasma amino acids. 2) Threonine plays a role in a hub in the network, which has direct links to the most number of other amino acids. 3) Threonine and methionine are interrelated to each other and form a loop structure. Springer-Verlag, 2006 Keywords: Plasma amino acids - Profile - Relation - Network - Threonine - Amino acid deficiency nationallicence Shikata N. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan aut Maki Y. Department of Digital Media, Fukuoka International University, Fukuoka, Japan aut Noguchi Y. Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki, Japan aut Mori M. Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki, Japan aut Hanai T. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan aut Takahashi M. Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki, Japan aut Okamoto M. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan aut Amino Acids Springer-Verlag 33/1(2007-07-01), 113-121 0939-4451 33:1<113 2007 33 726 https://doi.org/10.1007/s00726-006-0412-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0412-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shikata N. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Maki Y. Department of Digital Media, Fukuoka International University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Noguchi Y. Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki, Japan aut NATIONALLICENCE 700 1- Mori M. Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki, Japan aut NATIONALLICENCE 700 1- Hanai T. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takahashi M. Research Institute for Health Fundamentals, Ajinomoto Co., Inc., Kawasaki, Japan aut NATIONALLICENCE 700 1- Okamoto M. Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/1(2007-07-01), 113-121 0939-4451 33:1<113 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer