caa a22 4500 463186222 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00726-006-0390-2 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0390-2 L-methionine as immune supportive supplement: a clinical evaluation [Elektronische Daten] [R. Van Brummelen, D. du Toit] Summary.: The objective of the study was to test L-methioinine as a possible immune supportive supplement in HIV infected patients by means of a clinical study. A double-blind, placebo-controlled study was designed. The patients (n = 253) from four different trial centres were randomly divided into two groups, active and placebo, and regularly assessed by clinical and safety parameters. After six months from commencement, clinically and statistically significant differences were observed. The females of the active treatment group presented with a decreased level of decline in their CD4 counts (p = 0.0027), so also the patients of Centre 1 (p = 0.0377). All patients were placed onto active treatment after 12 months and were followed up for 48 months after the trial started. The same tendencies could be observed in the group as a whole, with no serious side effects directly associated to treatment. The study confirmed the supportive role of L-methionine in immune-compromised or deficient patients. Springer-Verlag, 2006 Keywords: L-methionine - Immune support - Supplement - HIV nationallicence Van Brummelen R. Tshwane University of Technology, Gezina, South Africa aut du Toit D. Tshwane University of Technology, Gezina, South Africa aut Amino Acids Springer-Verlag 33/1(2007-07-01), 157-163 0939-4451 33:1<157 2007 33 726 https://doi.org/10.1007/s00726-006-0390-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0390-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Van Brummelen R. Tshwane University of Technology, Gezina, South Africa aut NATIONALLICENCE 700 1- du Toit D. Tshwane University of Technology, Gezina, South Africa aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/1(2007-07-01), 157-163 0939-4451 33:1<157 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer