caa a22 4500 463186257 CHVBK 20180406164853.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s00726-006-0392-0 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0392-0 Selenomethionine induces polyamine biosynthesis in regenerating rat liver tissue [Elektronische Daten] [G. Bjelaković, S. Beninati, D. Pavlović, D. Sokolović, I. Stojanović, T. Jevtović, G. B. Bjelaković, J. Nikolić, J. Bašić] Summary.: Our study was undertaken to elucidate the effects of selenomethionine (SeMet) on polyamine metabolism in regenerating rat liver tissue, as useful model of rapidly growing normal tissue. We have examined the levels of spermine, spermidine and putrescine in liver tissue. At the same time we have evaluated the activities of polyamine oxidase (PAO) and diamine oxidase (DAO), the catabolic enzymes of polyamine metabolism. The obtained results suggest that polyamine levels in regenerating liver tissue, at 7th day after two-thirds partial hepatectomy, were higher in comparison with control group. The administration of selenomethionine to hepatectomized animals during seven days, in a single daily dose of 2.5 µg/100 g body weight, increases the amount of spermine and spermidine; the level of putrescine does not change under the influence of SeMet in regenerating rat liver tissue. PAO activity is lower in regenerating hepatic tissue than in control group. Supplementation of hepatectomized animals with SeMet significantly decreases the activity of this enzyme. DAO activity was significantly higher in hepatectomized and in operated animals treated with SeMet compared to the sham-operated and control ones. The differential sensitivity observed in our model of highly proliferating normal tissue to SeMet, compared with the reported anticancer activity of this molecule is discussed. Springer-Verlag, 2006 Keywords: Se-methionine - Polyamines - Polyamine oxidase - Diamine oxidase - Liver regeneration - Rats nationallicence Bjelaković G. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Beninati S. Department of Biology, University of Rome "Tor Vergata”, Rome, Italy aut Pavlović D. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Sokolović D. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Stojanović I. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Jevtović T. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Bjelaković G. B. Department of Hepato-Gastroenterology, Faculty of Medicine, University of Niš, Niš, Serbia aut Nikolić J. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Bašić J. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut Amino Acids Springer-Verlag 33/3(2007-09-01), 525-529 0939-4451 33:3<525 2007 33 726 https://doi.org/10.1007/s00726-006-0392-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0392-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bjelaković G. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Beninati S. Department of Biology, University of Rome "Tor Vergata”, Rome, Italy aut NATIONALLICENCE 700 1- Pavlović D. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Sokolović D. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Stojanović I. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Jevtović T. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Bjelaković G. B. Department of Hepato-Gastroenterology, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Nikolić J. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 700 1- Bašić J. Institute of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/3(2007-09-01), 525-529 0939-4451 33:3<525 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer