caa a22 4500 463186265 CHVBK 20180406164854.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s00726-006-0480-1 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0480-1 Extracellular amino acid levels in the human liver during transplantation: a microdialysis study from donor to recipient [Elektronische Daten] [D. A. Richards, M. A. Silva, N. Murphy, S. J. Wigmore, D. F. Mirza] Summary.: Using microdialysis, we have monitored extracellular levels of amino acids and related amines in the human liver at three stages of the transplantation procedure: donor retrieval, back table preparation and during 48 h post-implantation. By comparing the ratio of mean levels at the donor and back table stages, with the ratio between early (2-6 h) and late (43-48 h) post-reperfusion, these amines were classified into one of three groups. In one group, back table levels were markedly higher than during the donor stage, with levels declining over time post-reperfusion. A second group had much lower levels in the back table than during the donor phase, and post-reperfusion levels were either stable or increased over time. Concentrations of amino acids in the final group remained relatively constant at all stages. This study illustrates the value of microdialysis in providing organ-specific metabolic data that may indicate specific mechanisms of poor graft function. Springer-Verlag, 2007 Keywords: Liver - Transplantation - Microdialysis - Amino acids - Ethanolamine - Putrescine nationallicence Richards D. A. Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, Birmingham, U.K. aut Silva M. A. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K. aut Murphy N. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K. aut Wigmore S. J. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K. aut Mirza D. F. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K. aut Amino Acids Springer-Verlag 33/3(2007-09-01), 429-437 0939-4451 33:3<429 2007 33 726 https://doi.org/10.1007/s00726-006-0480-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0480-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richards D. A. Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, Birmingham, U.K aut NATIONALLICENCE 700 1- Silva M. A. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K aut NATIONALLICENCE 700 1- Murphy N. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K aut NATIONALLICENCE 700 1- Wigmore S. J. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K aut NATIONALLICENCE 700 1- Mirza D. F. The Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, U.K aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/3(2007-09-01), 429-437 0939-4451 33:3<429 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer