caa a22 4500 463186273 CHVBK 20180406164854.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s00726-006-0395-x doi (NATIONALLICENCE)springer-10.1007/s00726-006-0395-x Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and α-keto acid homeostasis or immunocompetence [Elektronische Daten] [J. Mühling, D. Burchert, T. W. Langefeld, R. Matejec, H. Harbach, J. Engel, M. Wolff, I. D. Welters, M. Fuchs, T. Menges, M. Krüll, G. Hempelmann] Summary.: We examined the effects of DON [glutamine-analogue and inhibitor of glutamine-requiring enzymes], alanyl-glutamine (regarding its role in neutrophil immunonutrition) and alanyl-glutamine combined with L-NAME, SNAP, DON, β-alanine and DFMO on neutrophil amino and α-keto acid concentrations or important neutrophil immune functions in order to establish whether an inhibitor of •NO-synthase [L-NAME], an •NO donor [SNAP], an analogue of taurine and a taurine transport antagonist [β-alanine], an inhibitor of ornithine-decarboxylase [DFMO] as well as DON could influence any of the alanyl-glutamine-induced effects. In summary, irrespective of which pharmacological, metabolism-inhibiting or receptor-mediated mechanisms were involved, our results showed that impairment of granulocytic glutamine uptake, modulation of intracellular glutamine metabolisation and/or de novo synthesis as well as a blockade of important glutamine-dependent metabolic processes may led to significant modifications of physiological and immunological functions of the affected cells. Springer-Verlag, 2006 Keywords: Alanyl-glutamine - DON - L-NAME - SNAP - β-Alanine - DFMO neutrophil - Amino acids - α-Keto acids - Immune function nationallicence Mühling J. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Burchert D. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Langefeld T. W. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Matejec R. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Harbach H. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Engel J. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Wolff M. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Welters I. D. University Department of Anaesthesia, Royal Liverpool University Hospital, Liverpool, U.K. aut Fuchs M. Dr. Ing. Herbert Knauer GmbH, Berlin, Federal Republic of Germany aut Menges T. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Krüll M. Department of Internal Medicine/Infectious Diseases, Charité, Medical School of Humboldt University, Berlin, Federal Republic of Germany aut Hempelmann G. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut Amino Acids Springer-Verlag 33/3(2007-09-01), 511-524 0939-4451 33:3<511 2007 33 726 https://doi.org/10.1007/s00726-006-0395-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0395-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mühling J. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Burchert D. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Langefeld T. W. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Matejec R. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Harbach H. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Engel J. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Wolff M. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Welters I. D. University Department of Anaesthesia, Royal Liverpool University Hospital, Liverpool, U.K aut NATIONALLICENCE 700 1- Fuchs M. Dr. Ing. Herbert Knauer GmbH, Berlin, Federal Republic of Germany aut NATIONALLICENCE 700 1- Menges T. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Krüll M. Department of Internal Medicine/Infectious Diseases, Charité, Medical School of Humboldt University, Berlin, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hempelmann G. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/3(2007-09-01), 511-524 0939-4451 33:3<511 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer