caa a22 4500 463186346 CHVBK 20180406164854.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s00726-006-0457-0 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0457-0 Bergamini C. M. Department of Biochemistry and Molecular Biology and Interdisciplinary Centre for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy aut Effects of ligands on the stability of tissue transglutaminase: studies in vitro suggest possible modulation by ligands of protein turn-over in vivo [Elektronische Daten] [C. M. Bergamini] Summary.: Tissue transglutaminase catalyzes irreversible post-translational modification of specific protein substrates by either crosslinkage or incorporation of primary amines into glutamine residues, through glutamyl-amide isopeptide bonds. Modulation in vivo of these reactions (collectively called "transamidation”) is brought about by both ligand dependent effects (chiefly, activation by calcium and inhibition by GTP) as well as by variation in enzyme tissue levels by transcriptional effects. Accumulating observations that the enzyme stability in vitro is greatly affected by interaction with ligands led us to postulate that also the turn-over in vivo might be modulated by ligands opening new scenarios on the regulation of the tissue transamidating activity. This proposal is consistent with data obtained in in vitro cell culture systems and has important implications for the expression of activity in vivo. Springer-Verlag, 2006 Keywords: Transglutaminase - Protein cross-links - GTP - Polyamines nationallicence Amino Acids Springer-Verlag 33/3(2007-09-01), 415-421 0939-4451 33:3<415 2007 33 726 https://doi.org/10.1007/s00726-006-0457-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0457-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bergamini C. M. Department of Biochemistry and Molecular Biology and Interdisciplinary Centre for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/3(2007-09-01), 415-421 0939-4451 33:3<415 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer