caa a22 4500 463186583 CHVBK 20180406164855.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00726-006-0464-1 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0464-1 Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry [Elektronische Daten] [I. Sahún, X. Gallego, M. Gratacòs, P. Murtra, R. Trullás, R. Maldonado, X. Estivill, M. Dierssen] Summary.: Sensitivity to pharmacological challenges has been reported in patients with panic disorder. We have previously validated transgenic mice overexpressing the neurotrophin-3 (NT-3) receptor, TrkC (TgNTRK3), as an engineered murine model of panic disorder. We could determine that TgNTRK3 mice presented increased cellularity in brain regions, such as the locus ceruleus, that are important neural substrates for the expression of anxiety in severe anxiety states. Here, we investigated the sensitivity to induce anxiety and panic-related symptoms by sodium lactate and the effects of various drugs (the α2-adrenoceptor antagonist, yohimbine and the adenosine antagonist, caffeine), in TgNTRK3 mice. We found enhanced panicogenic sensitivity to sodium lactate and an increased intensity and a differential pattern of Fos expression after the administration of yohimbine or caffeine in TgNTRK3. Our findings validate the relevance of the NT-3/TrkC system to pathological anxiety and raise the possibility that a specific set of fear-related pathways involved in the processing of anxiety-related information may be differentially activated in panic disorder. Springer-Verlag, 2006 Keywords: Panic disorder - Fos immunohistochemistry - Amygdala - Locus ceruleus - TrkC - NT-3 - Yohimbine - Caffeine nationallicence Sahún I. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut Gallego X. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut Gratacòs M. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut Murtra P. Unit of Neuropharmacology, Pompeu Fabra University, Barcelona, Spain aut Trullás R. Neurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain aut Maldonado R. Unit of Neuropharmacology, Pompeu Fabra University, Barcelona, Spain aut Estivill X. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut Dierssen M. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut Amino Acids Springer-Verlag 33/4(2007-11-01), 677-688 0939-4451 33:4<677 2007 33 726 https://doi.org/10.1007/s00726-006-0464-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0464-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sahún I. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut NATIONALLICENCE 700 1- Gallego X. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut NATIONALLICENCE 700 1- Gratacòs M. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut NATIONALLICENCE 700 1- Murtra P. Unit of Neuropharmacology, Pompeu Fabra University, Barcelona, Spain aut NATIONALLICENCE 700 1- Trullás R. Neurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain aut NATIONALLICENCE 700 1- Maldonado R. Unit of Neuropharmacology, Pompeu Fabra University, Barcelona, Spain aut NATIONALLICENCE 700 1- Estivill X. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut NATIONALLICENCE 700 1- Dierssen M. Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park (PRBB), Barcelona, Spain aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/4(2007-11-01), 677-688 0939-4451 33:4<677 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer