caa a22 4500 463186613 CHVBK 20180406164855.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s00726-006-0481-0 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0481-0 D-serine: a new word in the glutamatergic neuro-glial language [Elektronische Daten] [M. J. Scolari, G. B. Acosta] Summary.: Gliotransmission is a process in which astrocytes are dynamic elements that influence synaptic transmission and synaptogenesis. The best-known gliotransmitters are glutamate and ATP. However, in the past decade, it has been demonstrated that D-serine, a D-amino acid, acts as a gliotransmitter in glutamatergic synapses. The physiological relevance of D-serine is sustained by the way in which it modulates the action of glutamatergic neurotransmission, neuronal migration and long-term potentiation (LTP). In addition, the synthesis and degradation mechanisms of D-serine have been proposed as potential therapeutic targets for the treatment of Alzheimer's disease, schizophrenia and related disorders. In the present review, detailed information is provided about the physiological and physiopathological relevance of D-serine, including metabolic and regulation aspects. Springer-Verlag, 2007 Keywords: Gliotransmission - D-serine - Glutamate - NMDA - Glycine site nationallicence Scolari M. J. Instituto de Investigaciones Farmacológicas (ININFA-CONICET-UBA), Buenos Aires, Argentina aut Acosta G. B. Instituto de Investigaciones Farmacológicas (ININFA-CONICET-UBA), Buenos Aires, Argentina aut Amino Acids Springer-Verlag 33/4(2007-11-01), 563-574 0939-4451 33:4<563 2007 33 726 https://doi.org/10.1007/s00726-006-0481-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0481-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Scolari M. J. Instituto de Investigaciones Farmacológicas (ININFA-CONICET-UBA), Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Acosta G. B. Instituto de Investigaciones Farmacológicas (ININFA-CONICET-UBA), Buenos Aires, Argentina aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/4(2007-11-01), 563-574 0939-4451 33:4<563 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer