caa a22 4500 463186664 CHVBK 20180406164855.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0518-z doi (NATIONALLICENCE)springer-10.1007/s00726-007-0518-z Wang J.-Y Cell Biology Group, Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA aut Polyamines and mRNA stability in regulation of intestinal mucosal growth [Elektronische Daten] [J.-Y. Wang] Summary.: The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. Polyamines are necessary for normal intestinal mucosal growth and decreasing cellular polyamines inhibits cell proliferation and disrupts epithelial integrity. An increasing body of evidence indicates that polyamines regulate intestinal epithelial cell renewal by virtue of their ability to modulate expression of various genes and that growth inhibition following polyamine depletion results primarily from the activation of growth-inhibiting genes rather than a simple decrease in expression of growth-promoting genes. In this review article, we will focus on changes in expression of growth-inhibiting genes following polyamine depletion and further analyze in some detail the mechanisms through which mRNA stability is regulated by RNA-binding proteins. Springer-Verlag, 2007 Keywords: Intestinal epithelium - Cell proliferation and growth arrest - Posttranscriptional regulation - mRNA stability - RNA-binding proteins nationallicence AMPK : AMP-activated protein kinase nationallicence AP-1 : activator protein-1 nationallicence co-Smad : common-Smad nationallicence CR : coding region nationallicence CRE : cAMP responsive element nationallicence C-siRNA : control siRNA nationallicence DENSPM : N1, N11-diethylnorspermdine nationallicence DFMO : D,L-α-difluoromethylornithine nationallicence IEC : intestinal epithelial cell nationallicence I-Smads : inhibitory Smads nationallicence NPM : necleophosmin nationallicence ODC : ornithine decarboxylase nationallicence Q-PCR : real-time quantitative PCR nationallicence R-Smads : receptor-regulated Smads nationallicence siHuR : siRNA targeting HuR mRNA nationallicence siRNA : small interfering RNA nationallicence TGF-β : transforming growth factor-β nationallicence TGFβRII : TGF-β type II receptor nationallicence TRE : TPA responsive element nationallicence 3′-UTRs : 3′-untranslated regions nationallicence Amino Acids Springer-Verlag 33/2(2007-08-01), 241-252 0939-4451 33:2<241 2007 33 726 https://doi.org/10.1007/s00726-007-0518-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0518-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wang J.-Y Cell Biology Group, Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 241-252 0939-4451 33:2<241 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer