caa a22 4500 463186680 CHVBK 20180406164855.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0529-9 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0529-9 Satriano J. Division of Nephrology-Hypertension, Department of Medicine, The Veterans Administration San Diego Healthcare System, University of California San Diego, San Diego, CA, USA aut Kidney growth, hypertrophy and the unifying mechanism of diabetic complications [Elektronische Daten] [J. Satriano] Summary.: Michael Brownlee has proposed a ‘Unifying Mechanism' of hyperglycemia-induced damage in diabetes mellitus. At the crux of this hypothesis is the generation of reactive oxygen species (ROS), and their impact on glycolytic pathways. Diabetes is the leading cause of chronic kidney failure. In the early phase of diabetes, prior to establishment of proteinuria or fibrosis, comes kidney growth and hyperfiltration. This early growth phase consists of an early period of hyperplasia followed by hypertrophy. Hypertrophy also contributes to cellular oxidative stress, and may precede the ROS perturbation of glycolytic pathways described in the Brownlee proposal. This increase in growth promotes hyperfiltration, and along with the hypertrophic phenotype appears required for hyperglycemia-induced cell damage and the progression of downstream diabetic complications. Here we will evaluate this growth phenomenon in the context of diabetes mellitus. Springer-Verlag, 2007 Keywords: Type I diabetes - Hyperfiltration - Tubuloglomerular feedback - Reactive oxygen species - Polyamines - Hypertrophy nationallicence AGE : advanced glycation end products nationallicence Ang II : angiotensin II nationallicence APR : absolute proximal reabsorption nationallicence 4E-BP1 : eIF-4E binding protein-1 nationallicence BrdU : 5-bromodeoxyuridine nationallicence CKI : cyclin dependent kinase inhibitor nationallicence DAG : diacylglycerol nationallicence DFMO : difluoromethylornithine nationallicence ECM : extracellular matrix nationallicence EGF : epidermal growth factor nationallicence eIF-4E : eukaryotic initiation factor 4E nationallicence EMT : epithelial-to-mesenchymal transition nationallicence ERK1,2 : extracellular signal-regulated protein kinases nationallicence ESRD : end-stage renal disease nationallicence FGF : fibroblast growth factor nationallicence FPR : fractional proximal reabsorption nationallicence GAPDH : glyceraldehyde-3 phosphate dehydrogenase nationallicence GFR : glomerular filtration rate nationallicence HGF : hepatocyte growth factor nationallicence IGF-1 : insulin-like growth factor nationallicence MAPK : mitogen-activated protein kinases nationallicence MnSOD : manganese superoxide dismutase nationallicence mTOR : mammalian target of rapamycin nationallicence NF-κB : nuclear factor kappa B nationallicence ODC : ornithine decarboxylase nationallicence p27 : p27KIP1 nationallicence p27+/+ : p27KIP1 wild type mice nationallicence p27−/− : p27KIP1 deficient mice nationallicence PAI-1 : plasminogen activator inhibitor-1 nationallicence PCNA : proliferating cell nuclear antigen nationallicence PDGF : platelet-derived growth factor nationallicence PKC : protein kinase C nationallicence RAGE : receptor of advanced glycation end products nationallicence ROS : reactive oxygen species nationallicence STZ : streptozotocin nationallicence TGF-β : transforming growth factor-beta nationallicence TGF : tubuloglomerular feedback nationallicence UCP-1 : uncoupling protein-1 nationallicence VEGF : vascular endothelial growth factor nationallicence Amino Acids Springer-Verlag 33/2(2007-08-01), 331-339 0939-4451 33:2<331 2007 33 726 https://doi.org/10.1007/s00726-007-0529-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0529-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Satriano J. Division of Nephrology-Hypertension, Department of Medicine, The Veterans Administration San Diego Healthcare System, University of California San Diego, San Diego, CA, USA aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 331-339 0939-4451 33:2<331 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer