caa a22 4500 463186729 CHVBK 20180406164855.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0514-3 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0514-3 Polyamine biosynthesis as a target to inhibit apoptosis of non-tumoral cells [Elektronische Daten] [F. Flamigni, I. Stanic', A. Facchini, S. Cetrullo, B. Tantini, R. M. Borzì, C. Guarnieri, C. M. Caldarera] Summary.: Growing evidence suggests a role for polyamines in apoptosis, although the relationship appears to be complex. α-Difluoromethylornithine (DFMO), a largely used ornithine decarboxylase inhibitor, is cytostatic, hardly cytotoxic and may even increase the resistance of tumour cells to some apoptotic stimuli. This may represent a problem in cancer therapy, where the killing of tumoral cells would be a desired effect, but could be an advantage in other pathological contexts related to an excess of apoptosis, such as cardiovascular diseases, stem cell transplantation, arthritis and infections. In different cellular models, polyamine depletion following treatment with polyamine biosynthesis inhibitors appears to inhibit mitochondrial and death receptor pathways of apoptosis by affecting key proteins. These studies indicate that inhibition of polyamine biosynthesis may prevent or reduce the apoptotic response triggered by a variety of stimuli in non-tumoral cells, such as cardiac cells, stem cells, chondrocytes, macrophages and intestinal epithelial cells. Springer-Verlag, 2007 Keywords: Polyamines - Apoptosis - Signal transduction - Difluoromethylornithine - Caspases - Non-tumoral cells nationallicence ASK : apoptosis signal-regulating kinase nationallicence CHX : cycloheximide nationallicence DFMO : α-difluoromethylornithine nationallicence ERK : extracellular signal-regulated kinase nationallicence JNK : c-Jun-N-terminal kinase nationallicence ODC : ornithine decarboxylase nationallicence PP : protein phosphatase nationallicence SAM : S-adenosylmethionine nationallicence STAT : signal transducer and activator of transcription nationallicence TNF-α : tumor necrosis factor-α nationallicence Flamigni F. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut Stanic' I. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut Facchini A. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut Cetrullo S. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut Tantini B. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut Borzì R. M. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, I.O.R, Bologna, Italy aut Guarnieri C. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut Caldarera C. M. National Institute for Cardiovascular Research, Bologna, Italy aut Amino Acids Springer-Verlag 33/2(2007-08-01), 197-202 0939-4451 33:2<197 2007 33 726 https://doi.org/10.1007/s00726-007-0514-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0514-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flamigni F. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Stanic' I. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Facchini A. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Cetrullo S. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Tantini B. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Borzì R. M. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, I.O.R, Bologna, Italy aut NATIONALLICENCE 700 1- Guarnieri C. Department of Biochemistry "G. Moruzzi”, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Caldarera C. M. National Institute for Cardiovascular Research, Bologna, Italy aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 197-202 0939-4451 33:2<197 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer