caa a22 4500 463186745 CHVBK 20180406164855.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0533-0 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0533-0 Is there a role for eIF5A in translation? [Elektronische Daten] [C. F. Zanelli, S. R. Valentini] Summary.: The putative translation factor eIF5A is essential for cell viability and is highly conserved from archaebacteria to mammals. This factor is the only cellular protein that undergoes an essential posttranslational modification dependent on the polyamine spermidine, called hypusination. This review focuses on the functional characterization of eIF5A. Although this protein was originally identified as a translation initiation factor, subsequent studies did not support a role for eIF5A in general translation initiation. eIF5A has also been implicated in nuclear export of HIV-1 Rev and mRNA decay, but these findings are controversial in the literature and may reflect secondary effects of eIF-5A function. Next, the involvement of eIF5A and hypusination in the control of the cell cycle and proliferation in various organisms is reviewed. Finally, recent evidence in favor of reconsidering the role of eIF5A as a translation factor is discussed. Future studies may reveal the specific mechanism by which eIF5A affects protein synthesis. Springer-Verlag, 2007 Keywords: eIF5A - Hypusine - Ribosome - Translation - Protein synthesis nationallicence EF-P : elongation factor P protein nationallicence eIF5A : eukaryotic translation initiation factor 5A nationallicence GC7 : N1-guanyl-1,7-diaminoheptane nationallicence HIV : human immunodeficiency virus nationallicence Met-tRNAi : methyonyl initiator transfer RNA nationallicence RNAi : RNA interference nationallicence SELEX : systematic evolution of ligands by exponential enrichment nationallicence Zanelli C. F. Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil aut Valentini S. R. Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil aut Amino Acids Springer-Verlag 33/2(2007-08-01), 351-358 0939-4451 33:2<351 2007 33 726 https://doi.org/10.1007/s00726-007-0533-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0533-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zanelli C. F. Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil aut NATIONALLICENCE 700 1- Valentini S. R. Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 351-358 0939-4451 33:2<351 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer