caa a22 4500 463186753 CHVBK 20180406164856.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0524-1 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0524-1 Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients [Elektronische Daten] [B. G. Cipolla, R. Havouis, J. P. Moulinoux] Summary.: Polyamine contents were assessed by mass spectrometry in 233 current foods and beverages. In order to reduce gut polyamine uptake, a polyamine reduced diet (PRD) and partial intermittent intestinal tract decontamination (PIITD) with neomycin or nifuroxazide was proposed as nutritional therapy to 33 prostate carcinoma patients, 30 of whom with hormone refractory prostate cancer (HRPC). Mean PRD observance was 22 ± 19 (median: 16; range: 3-72) months. 10, 8 and 3 patients were respectively on PRD for more than 30, 36 and 64 months. No diet toxicity was observed. 8 patients had moderate intestinal intolerance due to PIITD which was interrupted. No significant differences in body weight, blood counts or serum protein levels were observed during the follow-up of patients under PRD. Performance status and pain scores were relatively stable during the trial with improved pain scores at 6 months. A PRD associated with intermittent PIITD is a safe and well observed nutritional regimen and long term observance is possible. Springer-Verlag, 2007 Keywords: Polyamines - Nutrition - Therapy - Prostate cancer - Pain - Performance status nationallicence Cd : Cadaverine nationallicence DFMO : difluoro-methylornithine nationallicence FIA : flow injection analysis nationallicence HRPC : hormone refractory prostate cancer nationallicence MS : ionization-mass spectrometry nationallicence ODC : ornithine-decarboxylase nationallicence PA : polyamine nationallicence PDD : polyamine deficient diet nationallicence PIITD : partial intermittent intestinal tract decontamination nationallicence PRD : polyamine reduced diet nationallicence PSA : Prostate Specific Antigen nationallicence Pt : putrescine nationallicence RBC : red blood cell nationallicence SAM : S-adenosyl-methionine nationallicence Sd : spermidine nationallicence Sm : spermine nationallicence WBC : white blood cells nationallicence Cipolla B. G. Department of Urology, Centre Hospitalier Privé Saint Grégoire, Saint Grégoire, France aut Havouis R. Groupe de Recherche en Thérapeutique Anticancéreuse, UPRES 3891, Faculté de Médecine - Centre Hospitalier Universitaire, Rennes, France aut Moulinoux J. P. Groupe de Recherche en Thérapeutique Anticancéreuse, UPRES 3891, Faculté de Médecine - Centre Hospitalier Universitaire, Rennes, France aut Amino Acids Springer-Verlag 33/2(2007-08-01), 203-212 0939-4451 33:2<203 2007 33 726 https://doi.org/10.1007/s00726-007-0524-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0524-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cipolla B. G. Department of Urology, Centre Hospitalier Privé Saint Grégoire, Saint Grégoire, France aut NATIONALLICENCE 700 1- Havouis R. Groupe de Recherche en Thérapeutique Anticancéreuse, UPRES 3891, Faculté de Médecine - Centre Hospitalier Universitaire, Rennes, France aut NATIONALLICENCE 700 1- Moulinoux J. P. Groupe de Recherche en Thérapeutique Anticancéreuse, UPRES 3891, Faculté de Médecine - Centre Hospitalier Universitaire, Rennes, France aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 203-212 0939-4451 33:2<203 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer