caa a22 4500 463186761 CHVBK 20180406164856.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0519-y doi (NATIONALLICENCE)springer-10.1007/s00726-007-0519-y Kahana C. Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel aut Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines [Elektronische Daten] [C. Kahana] Summary.: Protein degradation mediated by the ubiquitin/proteasome system is the major route for the degradation of cellular proteins. In this pathway the ubiquitination of the target proteins is manifested via the concerted action of several enzymes. The ubiquinated proteins are then recognized and degraded by the 26S proteasome. There are few reports of proteins degraded by the 26S protesome without ubiquitination, with ornithine decarboxylase being the most notable representative of this group. Interestingly, while the degradation of ODC is independent of ubiquitination, the degradation of other enzymes of the polyamine biosynthesis pathway is ubiquitin dependent. The present review describes the degradation of enzymes and regulators of the polyamine biosynthesis pathway. Springer-Verlag, 2007 Keywords: Ornithine decarboxylase - S-adenosylmethionine decarboxylase - Antizyme - Antizyme inhibitor - Protein degradation - Ubiquitin nationallicence AdoMet : S-adenosylmethionine nationallicence AdometDC : S-adenosylmethionine decarboxylase nationallicence Az : Antizyme nationallicence AzI : Antizyme inhibitor nationallicence NQO1 : NAD(P)H quinone oxidoreductase nationallicence ODC : ornithine decarboxylase nationallicence ORF : Open reading frame nationallicence Amino Acids Springer-Verlag 33/2(2007-08-01), 225-230 0939-4451 33:2<225 2007 33 726 https://doi.org/10.1007/s00726-007-0519-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0519-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kahana C. Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 225-230 0939-4451 33:2<225 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer