caa a22 4500 463186788 CHVBK 20180406164856.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0535-y doi (NATIONALLICENCE)springer-10.1007/s00726-007-0535-y Bachrach U. Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel aut Antiviral activity of oxidized polyamines [Elektronische Daten] [U. Bachrach] Summary.: Polyamines, oxidized by serum amine oxidase, yield aminoaldehydes and hydrogen peroxide. Acrolein may be formed from the aminoaldehydes by a spontaneous β-elimination process. These oxidation products "oxidized polyamines” inhibit bacterial growth and exhibit anticancer activity. The antimicrobial activity of oxidized polyamines is not limited to bacteria; and the inactivation of bacterial viruses, plant viruses and animal viruses, was also reported. Bacteriophages of the T-odd series are permeable and were inactivated by oxidized polyamines. The inactive phages absorb to their bacterial host and injected their DNA, which formed a stable inactive complex with the aminoaldehydes. Aminoaldehydes, synthesized chemically, also inactivated viruses. The growth of the plant viruses: Tobacco mosaic virus, Potato virus X and Alfalfa mosaic virus was also inhibited by oxidized polyamines. The animal viruses, which were inactivated by oxidized polyamines included Myxoviruses (influenza and Newcastle disease viruses), West Nile, vaccinia and Sindbis viruses. These findings may have practical implications. Springer-Verlag, 2007 Keywords: Oxidized polyamines - Aminoaldehydes - Acrolein - Inactivation of bacteriophages - Plant viruses - Animal viruses nationallicence Ox. Sp. : Oxidized spermine nationallicence p.f.u. : plaque forming units nationallicence SAO : serum amine oxidase nationallicence Amino Acids Springer-Verlag 33/2(2007-08-01), 267-272 0939-4451 33:2<267 2007 33 726 https://doi.org/10.1007/s00726-007-0535-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0535-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bachrach U. Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 267-272 0939-4451 33:2<267 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer