caa a22 4500 46318680X CHVBK 20180406164856.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0534-z doi (NATIONALLICENCE)springer-10.1007/s00726-007-0534-z Polyamine analogues - an update [Elektronische Daten] [H. M. Wallace, K. Niiranen] Summary.: The polyamines are growth factors in both normal and cancer cells. As the intracellular polyamine content correlates positively with the growth potential of that cell, the idea that depletion of polyamine content will result in inhibition of cell growth and, particularly tumour cell growth, has been developed over the last 15 years. The polyamine pathway is therefore a target for development of rationally designed, antiproliferative agents. Following the lessons from the single enzyme inhibitors (α-difluoromethylornithine DFMO), three generations of polyamine analogues have been synthesised and tested in vitro and in vivo. The analogues are multi-site inhibitors affecting multiple reactions in the pathway and thus prevent the up-regulation of compensatory reactions that have been the downfall of DFMO in anticancer chemotherapy. Although the initial concept was that the analogues may provide novel anticancer drugs, it now seems likely that the analogues will have wider applications in diseases involving hyperplasia. Springer-Verlag, 2007 Keywords: Cancer - Spermidine - Spermine - Polyamine analogues - DFMO - Disease nationallicence AOE-PU : N-[2-aminooxyethyl]-1,4-diaminobutane nationallicence APA : 1-aminooxy-3-aminopropane nationallicence AP-APA : 1-aminooxy-3-N-[3-aminopropyl]-aminopropane nationallicence BCNU : 1,3-bis(2-chloroethyl)-1-nitrosourea nationallicence BEHSpm/DEHSpm/BE-4-4-4 : N 1,N 14-bis(ethyl)-homospermine nationallicence BENSpm/DENSpm/BE-3-3-3 : N 1,N 11-bis(ethyl)-norspermine nationallicence BES : N 1,N 8-bis(ethyl)spermidine nationallicence BESpm/DESpm/BE-3-4-3 : N 1,N 12-bis(ethyl)spermine nationallicence CHENSpm : N 1-ethyl-N 11-((cycloheptyl)methyl)-4,8-diazaundecane nationallicence CPENSpm : N 1-ethyl-N 11-((cyclopropyl)methyl)-4,8-diazaundecane nationallicence DFMO : α-difluoromethylornithine nationallicence IPENSpm : N 1-ethyl-N 11-((isopropyl)methyl)-4,8-diazaundecane nationallicence MGBG : methylglyoxal bis(guanylhydrazone) nationallicence ODC : ornithine decarboxylase nationallicence SAMDC : S-adenosylmethionine decarboxylase nationallicence SSAT : spermidine/spermine N 1-acetyltransferase nationallicence Wallace H. M. Department of Medicine and Therapeutics, School of Medicine and School of Medical Sciences, University of Aberdeen, Aberdeen, UK aut Niiranen K. Department of Medicine and Therapeutics, School of Medicine and School of Medical Sciences, University of Aberdeen, Aberdeen, UK aut Amino Acids Springer-Verlag 33/2(2007-08-01), 261-265 0939-4451 33:2<261 2007 33 726 https://doi.org/10.1007/s00726-007-0534-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0534-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wallace H. M. Department of Medicine and Therapeutics, School of Medicine and School of Medical Sciences, University of Aberdeen, Aberdeen, UK aut NATIONALLICENCE 700 1- Niiranen K. Department of Medicine and Therapeutics, School of Medicine and School of Medical Sciences, University of Aberdeen, Aberdeen, UK aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 261-265 0939-4451 33:2<261 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer