caa a22 4500 463186885 CHVBK 20180406164856.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00726-007-0517-0 doi (NATIONALLICENCE)springer-10.1007/s00726-007-0517-0 Tissue transglutaminase and the stress response [Elektronische Daten] [R. Ientile, D. Caccamo, M. Griffin] Summary.: The expression of the protein crosslinking enzyme tissue transglutaminase (TG2, tTG), the ubiquitous member of transglutaminase family, can be regulated by multiple factors. Although it has been suggested that TG2 can be involved in apoptotic cell death, high levels of enzyme have also been associated with cell survival in response to different stimuli. Furthermore, evidence indicates that increases in TG2 production cause enzyme translocation to cell membrane. Cell stress can also lead to TG2 accumulation on the cell surface and in the extracellular matrix resulting in changes in cell-matrix interactions. Here, we discuss the underlying mechanisms of TG2 up-regulation induced by various stimuli including glutamate exposure, calcium influx, oxidative stress, UV, and inflammatory cytokines. These findings agree with a postulated role for transglutaminases in molecular mechanisms involved in several diseases suggesting that cross-linking reactions could be a relevant part of the biochemical changes observed in pathological conditions. Springer-Verlag, 2007 Keywords: Transglutaminases - Tissue transglutaminase - Neurodegeneration - Oxidative stress - Inflammation - Extracellular matrix nationallicence AMPA : α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid nationallicence CD : celiac disease nationallicence ECM : extracellular matrix nationallicence FN : fibronectin nationallicence GYKI 52466 : 1-(4′-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzo-diazepine nationallicence IFN-γ : interferon-γ nationallicence LPA : lysophosphatidic acid nationallicence TGF-beta : transforming growth factor-beta nationallicence MK-801 : (+)-5-Methyl-10,11-dihydro-5H-dibenzo [a, d]-cyclohepten-5,10-imine hydrogen maleate nationallicence NF-κB : nuclear factor-kappa B nationallicence NMDA : N-methyl-D-aspartic acid nationallicence 3-NP : 3-nitropropionic acid nationallicence PLA2 : phospholipase A2 nationallicence ROS : reactive oxygen species nationallicence TG(s) : transglutaminase(s) nationallicence TG2 : tissue transglutaminase nationallicence Ientile R. Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy aut Caccamo D. Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy aut Griffin M. School of Life and Health Sciences, Aston University, Birmingham, U.K. aut Amino Acids Springer-Verlag 33/2(2007-08-01), 385-394 0939-4451 33:2<385 2007 33 726 https://doi.org/10.1007/s00726-007-0517-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-007-0517-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ientile R. Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Caccamo D. Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Griffin M. School of Life and Health Sciences, Aston University, Birmingham, U.K aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 33/2(2007-08-01), 385-394 0939-4451 33:2<385 2007 33 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer