caa a22 4500 463188764 CHVBK 20180406164901.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10973-006-8001-8 doi (NATIONALLICENCE)springer-10.1007/s10973-006-8001-8 tudyon compatibility of imatinib mesylate with pharmaceutical excipients [Elektronische Daten] [M. Łaszcz, B. Kosmacińska, K. Korczak, B. Śmigielska, M. Glice, W. Maruszak, A. Groman, H. Beczkowicz, Ł. Żelazko] Differential scanning calorimetry and thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for the compatibility testing of imatinib mesylate, with following excipients: magnesium stearate, polyvinylpyrrolidone, microcrystalline cellulose. In order to maximize the probability of interactions 1:1 (by mass) drug: excipient binary mixtures were analysed and compared to individual components. Additionally an influence of storage at temperatures of 25 and 40°C on physico-chemical stability on drug - excipient binary mixtures was investigated. The largest visible changes were observed in the DSC curves of imatinib mesylate - magnesium stearate mixtures. Springer-Verlag, 2007 compatibility nationallicence drug-excipient interactions nationallicence DSC nationallicence infrared spectroscopy nationallicence TG nationallicence X-ray powder diffraction nationallicence Łaszcz M. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Kosmacińska B. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Korczak K. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Śmigielska B. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Glice M. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Maruszak W. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Groman A. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Beczkowicz H. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Żelazko Ł. Pharmaceutical Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 305-310 1388-6150 88:2<305 2007 88 10973 https://doi.org/10.1007/s10973-006-8001-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8001-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Łaszcz M. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Kosmacińska B. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Korczak K. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Śmigielska B. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Glice M. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Maruszak W. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Groman A. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Beczkowicz H. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 700 1- Żelazko Ł. Pharmaceutical Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793, Warsaw, Poland aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 305-310 1388-6150 88:2<305 2007 88 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer