caa a22 4500 463188993 CHVBK 20180406164903.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10973-006-8007-2 doi (NATIONALLICENCE)springer-10.1007/s10973-006-8007-2 Developmentof thermogravimetric method for quantitative determination of metronidazole [Elektronische Daten] [Ana Gomes, Lidiane Correia, Mônica da Silva Simões, R. Macêdo] The objective of this work was to develop and validate a fast and reproducible method to determine the concentration of metronidazole in drug substance and tablets. The samples were analyzed by dynamic thermogravimetry, using 10, 20, 40, 60 and 80°C min-1 heating rates in nitrogen and in nitrogen with synthetic air. Obtained data were used in the Antoine and Langmuir equations in order to have the pressure curves. Vapor pressure curves of drug and tablet of metronidazole were evaluated using the mathematical indexes of difference factor, f 1, and similarity factor, f 2, to compare their profiles. The data showed that there is no significant difference between the vapor pressure profiles of drug and tablet of metronidazole in both environmental conditions, which confirms that the process is really vaporization. The concentration of metronidazole was determined in the raw material and tablets of the drug. Springer-Verlag, 2007 Antoine equation nationallicence Langmuir equation nationallicence metronidazole nationallicence thermogravimetry nationallicence vapor pressure nationallicence Gomes Ana Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut Correia Lidiane Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut da Silva Simões Mônica Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut Macêdo R. Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 383-387 1388-6150 88:2<383 2007 88 10973 https://doi.org/10.1007/s10973-006-8007-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8007-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gomes Ana Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut NATIONALLICENCE 700 1- Correia Lidiane Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut NATIONALLICENCE 700 1- da Silva Simões Mônica Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut NATIONALLICENCE 700 1- Macêdo R. Unified Development and Medicine Assays Laboratories - LUDEM, Federal University of Paraíba - UFPB, Cidade Universitária, Campus I - CCS, 58051-970, João Pessoa, Paraíba, Brasil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 383-387 1388-6150 88:2<383 2007 88 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer