caa a22 4500 463189000 CHVBK 20180406164903.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10973-006-8060-x doi (NATIONALLICENCE)springer-10.1007/s10973-006-8060-x Thermalstudy of four irradiated imidazoline derivatives in solid state [Elektronische Daten] [Barbara Marciniec, M. Kozak, M. Naskrent, K. Dettlaff, M. Ogrodowczyk, M. Stawny, L. Wachowski] Four imidazoline derivatives: antazoline (AN), naphazoline (NN), tymazoline (TM), xylometazoline (XM), in the form of hydrochlorides in solid phase have been subjected to high energy e-beam irradiation from an accelerator (~10 MeV) at a dose varied from 25 to 200 kGy. The effects of the irradiation have been assessed by DSC, X-ray diffraction, FTIR, EPR and TLC. The standard sterilisation dose of 25 kGy has been found to produce changes in the properties of one derivative (XM), two other ones (AN and TM) have been found sensitive to doses >100 kGy, whereas NN has been resistant to irradiation in the whole range studied (25-200 kGy). EPR results indicated that the changes taking place in the therapeutic substances studied are related to radical formation. The irradiation induced changes in colour, a decrease or increase in the melting point, changes in the XRD pattern, small changes in the shape of FTIR peaks and the presence of radiolysis products. The XM compounds cannot be sterilised by irradiation because of the radiation induced changes in its physico-chemical properties. Springer-Verlag, 2007 antazoline nationallicence DSC nationallicence EPR nationallicence FTIR nationallicence naphazoline nationallicence TLC nationallicence tymazoline nationallicence XRD nationallicence xylometazoline nationallicence Marciniec Barbara Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut Kozak M. Department of Macromolecular Physics, A. Mickiewicz University, Umultowska 85, 60-614, Poznań, Poland aut Naskrent M. Department of Medical Physics, A. Mickiewicz University, Umultowska 85, 60-614, Poznań, Poland aut Dettlaff K. Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut Ogrodowczyk M. Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut Stawny M. Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut Wachowski L. Department of Cooridinational Chemistry, A. Mickiewicz University, Gruwaldzka 6, 60-780, Poznań, Poland aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 337-342 1388-6150 88:2<337 2007 88 10973 https://doi.org/10.1007/s10973-006-8060-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8060-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marciniec Barbara Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 700 1- Kozak M. Department of Macromolecular Physics, A. Mickiewicz University, Umultowska 85, 60-614, Poznań, Poland aut NATIONALLICENCE 700 1- Naskrent M. Department of Medical Physics, A. Mickiewicz University, Umultowska 85, 60-614, Poznań, Poland aut NATIONALLICENCE 700 1- Dettlaff K. Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 700 1- Ogrodowczyk M. Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 700 1- Stawny M. Department of Pharmaceutical Chemistry, Poznań University of Medical Sciences, Gruwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 700 1- Wachowski L. Department of Cooridinational Chemistry, A. Mickiewicz University, Gruwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 337-342 1388-6150 88:2<337 2007 88 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer