caa a22 4500 463189035 CHVBK 20180406164903.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10973-006-8006-3 doi (NATIONALLICENCE)springer-10.1007/s10973-006-8006-3 Thermalstability of paracetamol and its pre-formulates obtained by spray drying [Elektronische Daten] [Antonilêni Medeiros, Ana Santos, F. de Souza, J. Procópio, Márcia Pinto, R. Macêdo] Stability of drugs and products has a great practical interest, which is facing to strict regulation. Thermal studies, besides the determination of the thermal properties of the investigated product allow the verification of possible interactions between the drug substances and excipients. The objective of this work was to obtain solid pre-formulates of paracetamol (PC) by spray drying (SPDR), as well as to investigate their thermal behavior. Dynamic and isotherm TG, conventional DSC and DSC-photovisual coupled methods were used to characterize the conventional and pre-formulated mixtures obtained by SPDR. The results of both DSC investigations showed slight alterations in melting temperatures, which suggests incompatibilities. The TG decomposition data of the mixtures evidenced that the dry process via SPDR leads to stability enhancement of the pre-formulated mixtures. Springer-Verlag, 2007 paracetamol nationallicence spray drying nationallicence thermal analysis nationallicence Medeiros Antonilêni Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil aut Santos Ana Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil aut de Souza F. Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba - UFPB, Campus I, 58059-900, João Pessoa, PB, Brazil aut Procópio J. Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba - UFPB, Campus I, 58059-900, João Pessoa, PB, Brazil aut Pinto Márcia Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba - UFPB, Campus I, 58059-900, João Pessoa, PB, Brazil aut Macêdo R. Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 377-382 1388-6150 88:2<377 2007 88 10973 https://doi.org/10.1007/s10973-006-8006-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8006-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Medeiros Antonilêni Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil aut NATIONALLICENCE 700 1- Santos Ana Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil aut NATIONALLICENCE 700 1- de Souza F. Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba - UFPB, Campus I, 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Procópio J. Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba - UFPB, Campus I, 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Pinto Márcia Unified Laboratories of Medicine Development and Assay - LUDEM, Federal University of Paraíba - UFPB, Campus I, 58059-900, João Pessoa, PB, Brazil aut NATIONALLICENCE 700 1- Macêdo R. Pharmaceutical Sciences Department, Federal University of Pernambuco - UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers 88/2(2007-05-01), 377-382 1388-6150 88:2<377 2007 88 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer