caa a22 4500 463190394 CHVBK 20180406164907.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10973-007-8395-y doi (NATIONALLICENCE)springer-10.1007/s10973-007-8395-y Influence of high energy milling on the kinetics of the polymorphic transition from the monoclinic form to the orthorhombic form of (±)5-methyl-5-(4'-methylphenyl)hydantoin [Elektronische Daten] [J. Linol, G. Coquerel] 5-methyl-5-(4'-methylphenyl) hydantoin is a chiral compound whose racemic mixture crystallizes as a conglomerate. This molecule has two polymorphs: an orthorhombic form (stable form) and a monoclinic form of monotropic character. These forms share extensive structural analogies (identical 2D periodic fragment) and consistently their lattice energies are quite close. The analyses of the crystal structures lead to propose an irreversible polymorphic transition based on a destructive/reconstructive mechanism. Under comparable conditions (mass of solid, temperature, etc.) the conversion is completed within 14 days by means of slurring in ethanol (10 days if seeded) whereas 5 h only are necessary by means of mechanical activation under wet conditions and 9 h under dry milling. In the latter conditions the resulting materials appears significantly more defective in comparisons to the other modes of conversion. Springer Science+Business Media, LLC., 2007 high energy milling nationallicence polymorphism nationallicence transition kinetics nationallicence Linol J. Unité de Croissance Cristalline et de Modélisation Moléculaire, SMS, UPRES EA3233-IRCOF, Université de Rouen, 76821, Mont Saint Aignan Cedex, France aut Coquerel G. Unité de Croissance Cristalline et de Modélisation Moléculaire, SMS, UPRES EA3233-IRCOF, Université de Rouen, 76821, Mont Saint Aignan Cedex, France aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 90/2(2007-11-01), 367-370 1388-6150 90:2<367 2007 90 10973 https://doi.org/10.1007/s10973-007-8395-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-007-8395-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Linol J. Unité de Croissance Cristalline et de Modélisation Moléculaire, SMS, UPRES EA3233-IRCOF, Université de Rouen, 76821, Mont Saint Aignan Cedex, France aut NATIONALLICENCE 700 1- Coquerel G. Unité de Croissance Cristalline et de Modélisation Moléculaire, SMS, UPRES EA3233-IRCOF, Université de Rouen, 76821, Mont Saint Aignan Cedex, France aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 90/2(2007-11-01), 367-370 1388-6150 90:2<367 2007 90 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer