caa a22 4500 463190580 CHVBK 20180406164907.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10973-007-8390-3 doi (NATIONALLICENCE)springer-10.1007/s10973-007-8390-3 Thermal behavior of orthorhombic polymorphs I and II of spironolactone [Elektronische Daten] [P. Espeau, B. Nicolaï, R. Céolin, M. Perrin, L. Zaske, J. Giovannini, F. Leveiller] Investigation into the thermal behavior of orthorhombic Forms I and II of spironolactone, by means of differential scanning calorimetry and high-resolution X-ray powder diffraction, showed that Form I melts then recrystallizes into Form II at 373-393 K, i.e. in the temperature range within which high resolution X-ray powder diffration showed that Form I transforms into Form II. Refinements of the lattice parameters of the two forms indicated that Form I is denser than Form II in the range from 298 K up to the temperature at which it melts. Springer Science+Business Media, LLC., 2007 differential scanning calorimetry nationallicence spironolactone nationallicence polymorphism nationallicence X-ray powder diffraction nationallicence Espeau P. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut Nicolaï B. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut Céolin R. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut Perrin M. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut Zaske L. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut Giovannini J. AstraZeneca R and D, 221 87, Lund, Sweden aut Leveiller F. AstraZeneca R and D, 221 87, Lund, Sweden aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 90/2(2007-11-01), 341-342 1388-6150 90:2<341 2007 90 10973 https://doi.org/10.1007/s10973-007-8390-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-007-8390-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Espeau P. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut NATIONALLICENCE 700 1- Nicolaï B. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut NATIONALLICENCE 700 1- Céolin R. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut NATIONALLICENCE 700 1- Perrin M. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut NATIONALLICENCE 700 1- Zaske L. Laboratoire de Chimie Physique, EA 4066, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France aut NATIONALLICENCE 700 1- Giovannini J. AstraZeneca R and D, 221 87, Lund, Sweden aut NATIONALLICENCE 700 1- Leveiller F. AstraZeneca R and D, 221 87, Lund, Sweden aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 90/2(2007-11-01), 341-342 1388-6150 90:2<341 2007 90 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer