caa a22 4500 463190858 CHVBK 20180406164908.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s10973-006-8534-x doi (NATIONALLICENCE)springer-10.1007/s10973-006-8534-x Solubility diagrams in solvent-antisolvent systems by titration calorimetry [Elektronische Daten] Application to some pharmaceutical compounds in water-ethanol mixtures [M. Hamedi, J. Grolier] Isothermal titration calorimetry (ITC) has been used to develop a method to construct the solid-liquid equilibrium line in ternary systems containing the solute to precipitate and an aqueous mixed solvent. The method consists in measuring the heat of dissolution of a solid component (the solute) during successive additions of the liquid solvent. The cumulated heat, resulting from the successive heat peaks obtained for the different injections of known volumes of solvent, plotted vs. the ratio of the numbers of moles n solvent/n solute is represented by two nearly straight lines. The intercept of the two lines gives the solubility limit and the corresponding enthalpy of dissolution of the solute in the solvent. Solubility diagrams have been established at 303.15 K in binary mixed solvents ethanol-water over the whole concentration range for seven compounds of pharmaceutical interest, namely: urea, phenylurea, l-valine, dl-valine, l-valine ethyl ester hydrochloride, tris(hydroxymethyl)amino methane. Springer Science+Business Media LLC, 2007 heat of dissolution nationallicence phenylurea nationallicence purine nationallicence solid-liquid equilibrium nationallicence solubility nationallicence ternary systems nationallicence titration calorimetry nationallicence tris(hydroxymethyl)amino methane nationallicence urea nationallicence valine nationallicence Hamedi M. Mechanical Engineering Department, K. N. Toosi University of Technology, East Vafadar Ave., Tehran, Iran aut Grolier J. Laboratory of Thermodynamics of Solutions and Polymers, University Blaise Pascal, 24 des Landais Ave., 63177, Aubière, France aut Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 89/1(2007-07-01), 87-92 1388-6150 89:1<87 2007 89 10973 https://doi.org/10.1007/s10973-006-8534-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-8534-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hamedi M. Mechanical Engineering Department, K. N. Toosi University of Technology, East Vafadar Ave., Tehran, Iran aut NATIONALLICENCE 700 1- Grolier J. Laboratory of Thermodynamics of Solutions and Polymers, University Blaise Pascal, 24 des Landais Ave., 63177, Aubière, France aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 89/1(2007-07-01), 87-92 1388-6150 89:1<87 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer