caa a22 4500 463191102 CHVBK 20180406164909.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-006-7957-8 doi (NATIONALLICENCE)springer-10.1007/s10973-006-7957-8 Investigating carbamazepine-acetone solvate formation via Dynamic gravimetric Vapor Sorption [Elektronische Daten] [D. Burnett, F. Thielmann, T. Sokoloski] Pharmaceutical solids can often form solvated species which can affect the material's physical and chemical stability. Carbamazepine (CBZ) has been proven to form a 1:1 solvate with acetone. This report investigates the solvation behavior of CBZ over a wide temperature and acetone concentration range using Dynamic gravimetric Vapor Sorption (DVS). The solvation transition point increased from 62.5% P/P 0 at 10°C to 97.8% P/P 0 at 30°C, resulting in a 15.9 kJ mol−1 heat of solvation. The desolvation kinetics were studied between 15 and 30°C, indicating CBZ desolvation is a first-order reaction with autocatalysis by the desolvated product and an activation energy of 81.9 kJ mol−1. Springer Science+Business Media LLC, 2007 acetone nationallicence amorphicity nationallicence carbamazepine nationallicence dynamic vapor sorption nationallicence solid-state transitions nationallicence solvate nationallicence Burnett D. Surface Measurement Systems, Ltd., 2222 South 12th Street, Suite D, 18103, Allentown, PA, USA aut Thielmann F. Surface Measurement Systems, Ltd., 5 Wharfside, Rosemont Road, HA0 4PE, Alperton, Middlesex, UK aut Sokoloski T. Emeritus status, The Ohio State University, College of Pharmacy, 500 West 12th Avenue, 43210, Columbus, OH, USA aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 693-698 1388-6150 89:3<693 2007 89 10973 https://doi.org/10.1007/s10973-006-7957-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-006-7957-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burnett D. Surface Measurement Systems, Ltd., 2222 South 12th Street, Suite D, 18103, Allentown, PA, USA aut NATIONALLICENCE 700 1- Thielmann F. Surface Measurement Systems, Ltd., 5 Wharfside, Rosemont Road, HA0 4PE, Alperton, Middlesex, UK aut NATIONALLICENCE 700 1- Sokoloski T. Emeritus status, The Ohio State University, College of Pharmacy, 500 West 12th Avenue, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 693-698 1388-6150 89:3<693 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer