caa a22 4500 46319120X CHVBK 20180406164909.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10973-007-8397-9 doi (NATIONALLICENCE)springer-10.1007/s10973-007-8397-9 Identification of an enantiotropic system with hindered multiphase transitions [Elektronische Daten] Reexamination of polymorphism in carbamazepine [G. Defossemont, S. Randzio, B. Legendre] A determination of the enthalpy increments for single phases of polymorphs through exact calorimetric measurements of respective heat capacities in stable and metastable regions, determination of the enthalpy increments for the liquid phase through dynamic measurements in the glassy state and separate measurements of the heat of fusion of polymorphs created precise data base which permitted to use the heat-of-fusion rule in a rigorous way and to verify univocally that the polymorphs III and I in carbamazepine form an enantiotropic system. The approach elaborated in the present study can be used in identification of all difficult polymorphic systems, where the solid-solid transitions have a complicated nature, are kinetically driven or hindered by other constraints. Springer Science+Business Media LLC, 2007 carbamazepine nationallicence heat-of-fusion rule nationallicence hindered transitions nationallicence metastable phases nationallicence polymorphism nationallicence Defossemont G. Faculté de Pharmacie, Laboratoire de Chimie Physique Minérale et Bioinorganique, EA 401, 5 rue J.B. Clément, 92290, Châtenay-Malabry, France aut Randzio S. Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warszawa, Poland aut Legendre B. Faculté de Pharmacie, Laboratoire de Chimie Physique Minérale et Bioinorganique, EA 401, 5 rue J.B. Clément, 92290, Châtenay-Malabry, France aut Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 751-755 1388-6150 89:3<751 2007 89 10973 https://doi.org/10.1007/s10973-007-8397-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10973-007-8397-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Defossemont G. Faculté de Pharmacie, Laboratoire de Chimie Physique Minérale et Bioinorganique, EA 401, 5 rue J.B. Clément, 92290, Châtenay-Malabry, France aut NATIONALLICENCE 700 1- Randzio S. Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warszawa, Poland aut NATIONALLICENCE 700 1- Legendre B. Faculté de Pharmacie, Laboratoire de Chimie Physique Minérale et Bioinorganique, EA 401, 5 rue J.B. Clément, 92290, Châtenay-Malabry, France aut NATIONALLICENCE 773 0- Journal of Thermal Analysis and Calorimetry Springer US; http://www.springer-ny.com 89/3(2007-09-01), 751-755 1388-6150 89:3<751 2007 89 10973 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer